HG-9-91-01
- CAS No.
- 1456858-58-4
- Chemical Name:
- HG-9-91-01
- Synonyms
- HG-9-91-01;SIK INHIBITOR 1;Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea;N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea;Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-
- CBNumber:
- CB32676109
- Molecular Formula:
- C32H37N7O3
- Molecular Weight:
- 567.68
- MDL Number:
- MFCD28167714
- MOL File:
- 1456858-58-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
HG-9-91-01 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19179 | HG-9-91-01 ≥95% | 1456858-58-4 | 500μg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 19179 | HG-9-91-01 ≥95% | 1456858-58-4 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 19179 | HG-9-91-01 ≥95% | 1456858-58-4 | 5mg | $505 | 2024-03-01 | Buy |
| Cayman Chemical | 19179 | HG-9-91-01 ≥95% | 1456858-58-4 | 10mg | $884 | 2024-03-01 | Buy |
| ApexBio Technology | B1052 | HG-9-91-01 | 1456858-58-4 | 50mg | $795 | 2021-12-16 | Buy |
HG-9-91-01 Chemical Properties,Uses,Production
Definition
ChEBI: HG-9-91-01 is a member of the class of phenylureas that is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer. It has a role as an antineoplastic agent and a salt-inducible kinase 2 inhibitor. It is a dimethoxybenzene, an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a secondary amino compound and a member of phenylureas.
Biological Activity
hg-9-91-01 is a pan-sik (salt-inducible kinases) inhibitor with ic50 values of 0.92nm, 6.6nm and 9.6nm for sik1, sik2, sik3, respectively [1].siks restrict the formation of regulatory macrophages. the inhibition of these enzymes is thought to have potential for treating inflammatory and autoimmune diseases. hg-9-91-01 potently inhibits siks through targeting both the atp-binding site and the small hydrophobic pocket. it is reported that, besides siks, hg-9-91-01 also inhibits various protein tyrosine kinases such as src, btk, fgf and ephrin receptors. but other ampk-related kinase subfamily members are not sensitive to hg-9-91-01. hg-9-91-01 can promote lps-stimulated il-10 production, creb-dependent gene transcription, inhibit proinflammatory cytokine secretion and induce the expression of regulatory macrophage markers [1].
References
[1] clark k, mackenzie k f, petkevicius k, et al. phosphorylation of crtc3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. proceedings of the national academy of sciences, 2012, 109(42): 16986-16991.
HG-9-91-01 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |