TM 5275
- CAS No.
- 1103926-82-4
- Chemical Name:
- TM 5275
- Synonyms
- CS-2524;TM 5275;TM5275 Na;TM 5275;TM-5275;TM5275 (sodium);TM 5275 sodium salt;TM5275 sodium salt >=98% (HPLC);2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoic acid sodium salt;5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt;Plasminogen activator inhibitor-1,PAI-1,TM5275,TM5275 sodium,TM-5275 sodium,TM-5275,inhibit,TM 5275,Inhibitor
- CBNumber:
- CB33146397
- Molecular Formula:
- C28H29ClN3NaO5
- Molecular Weight:
- 546
- MDL Number:
- MFCD28396414
- MOL File:
- 1103926-82-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| NFPA 704 |
|
TM 5275 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1398 | TM5275 sodium salt ≥98% (HPLC) | 1103926-82-4 | 5MG | $211 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1398 | TM5275 sodium salt ≥98% (HPLC) | 1103926-82-4 | 25MG | $745 | 2023-06-20 | Buy |
| Cayman Chemical | 23151 | TM5275 ≥95% | 1103926-82-4 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 23151 | TM5275 ≥95% | 1103926-82-4 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 23151 | TM5275 ≥95% | 1103926-82-4 | 25mg | $396 | 2024-03-01 | Buy |
TM 5275 Chemical Properties,Uses,Production
Description
TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 6.95 μM), a serine-protease inhibitor involved in thrombosis. TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs. It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis. TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.
Uses
TM 5275 Sodium Salt is a novel inhibitor of plasminogen activator inhibitor-1 (PAI-1), which provides antithrombitic benefits devoid of bleeding in primates.
Biochem/physiol Actions
TMS5275 is an orally available, potent and selective inhibitor of PAI-1 that delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates.
storage
Store at +4°C
TM 5275 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4663 | 58 |
