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PE859

PE859 Structure
PE859 structure
CAS No.
1402727-29-0
Chemical Name:
PE859
Synonyms
PE859;PE-859; PE 859;AMBZHNVCLPHAKA-NSJFVGFPSA-N;PE 859,PE-859,Inhibitor,inhibit,Microtubule/Tubulin,PE859;1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-
CBNumber:
CB33161550
Molecular Formula:
C28H24N4O2
Molecular Weight:
448.52
MDL Number:
MFCD28411710
MOL File:
1402727-29-0.mol
Last updated:2023-05-21 10:59:17
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PE859 Properties

Boiling point 747.7±60.0 °C(Predicted)
Density 1.312±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (111.48 mM);Water : < 0.1 mg/mL (insoluble)
pka 13.78±0.10(Predicted)

PE859 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M267212 6-((E)-2-(3-((E)-2-Methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-5-yl)vinyl)-1H-indole 1402727-29-0 2.5mg $800 2021-12-16 Buy
ChemScene CS-6428 PE859 99.84% 1402727-29-0 10mg $600 2021-12-16 Buy
ChemScene CS-6428 PE859 99.84% 1402727-29-0 1mg $132 2021-12-16 Buy
ChemScene CS-6428 PE859 99.84% 1402727-29-0 5mg $396 2021-12-16 Buy
ChemScene CS-6428 PE859 99.84% 1402727-29-0 50mg $1800 2021-12-16 Buy
Product number Packaging Price Buy
M267212 2.5mg $800 Buy
CS-6428 10mg $600 Buy
CS-6428 1mg $132 Buy
CS-6428 5mg $396 Buy
CS-6428 50mg $1800 Buy

PE859 Chemical Properties,Uses,Production

Uses

6-((E)-2-(3-((E)-2-Methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-5-yl)vinyl)-1H-indole is a potent tau aggregation inhibitor that functions as a drug for Alzheimer’s disease.

Enzyme inhibitor

This orally bioavailable tau aggregation inhibitor (FW = 448.53 g/mol; IUPAC: 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2- pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole) significantly reduces formation of sarkosyl-insoluble aggregates of Tau, the principal axonal microtubule-associated protein, and prevents onset and progression of the motor dysfunction in JNPL3 Pro-301-Leu-mutated human tau transgenic mice. PE859 also inhibits aggregation of three-repeat Tau, or 3RMBD-Tau (IC50 = 0.81 μM), and four-repeat Tau, or 2N4R-Tau (IC50 = 2.23 μM).

PE859 Preparation Products And Raw materials

Raw materials

Preparation Products

PE859 Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Hangzhou ChangCun Biotechnology Co., Ltd. 0571-; 13567100326 158848739@qq.com China 108 50
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1836 55
Twochem Co.Ltd. 021-58111628 15800915896 China 1988 58
Angel Pharmatech, Ltd. 17317130613 3358272972@qq.com China 3244 58
Supplier Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Hangzhou ChangCun Biotechnology Co., Ltd. 50
ShangHai Biochempartner Co.,Ltd 62
Chuzhou KeMail Chemical Technology Co., Ltd 55
Twochem Co.Ltd. 58
Angel Pharmatech, Ltd. 58
PE859 AMBZHNVCLPHAKA-NSJFVGFPSA-N PE-859; PE 859 1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]- PE 859,PE-859,Inhibitor,inhibit,Microtubule/Tubulin,PE859 1402727-29-0