RIPA-56
- CAS No.
- 1956370-21-0
- Chemical Name:
- RIPA-56
- Synonyms
- RIPA-56;RIPA56; RIPA 56;RIPA-56 >=98% (HPLC);N-Benzyl-N-hydroxy-2,2-dimethylbutanamide;Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-;RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56
- CBNumber:
- CB33167633
- Molecular Formula:
- C13H19NO2
- Molecular Weight:
- 221.3
- MDL Number:
- MOL File:
- 1956370-21-0.mol
- MSDS File:
- SDS
| Boiling point | 346.0±35.0 °C(Predicted) |
|---|---|
| Density | 1.070±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml) |
| form | solid |
| pka | 9.42±0.50(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
RIPA-56 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2100 | RIPA-56 ≥98% (HPLC) | 1956370-21-0 | 5MG | $64.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2100 | RIPA-56 ≥98% (HPLC) | 1956370-21-0 | 25MG | $198 | 2024-03-01 | Buy |
| Axon Medchem | Axon2677 | RIPA-56 99% | 1956370-21-0 | 50mg | $132 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546233 | RIPA-56 ??? >98% | 1956370-21-0 | 10mg | $136 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546233 | RIPA-56 ??? >98% | 1956370-21-0 | 50mg | $307.7 | 2021-12-16 | Buy |
RIPA-56 Chemical Properties,Uses,Production
Description
RIPA-56 (1956370-21-0) is a potent (IC50?= 13 nM, EC50?= 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2?= 128min human liver microsomal stability assay).? RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 μM.?It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2
Biochem/physiol Actions
RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50?= 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice.
storage
Store at -20°C
References
1) Ren?et al.?(2017),?Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem.?60?972
RIPA-56 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |