KDU691
- CAS No.
- 1513879-19-0
- Chemical Name:
- KDU691
- Synonyms
- KDU691;KDU691 >=98% (HPLC);KDU691;KDU-691;KDU 691;1513879-19-0;Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-;PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
- CBNumber:
- CB33384777
- Molecular Formula:
- C22H18ClN5O2
- Molecular Weight:
- 419.86
- MDL Number:
- MOL File:
- 1513879-19-0.mol
KDU691 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29019 | KDU691 | 1513879-19-0 | 1mg | $59 | 2024-03-01 | Buy |
| Cayman Chemical | 29019 | KDU691 | 1513879-19-0 | 25mg | $699 | 2024-03-01 | Buy |
| Cayman Chemical | 29019 | KDU691 | 1513879-19-0 | 5mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 29019 | KDU691 | 1513879-19-0 | 10mg | $336 | 2024-03-01 | Buy |
| TRC | K145605 | KDU691 | 1513879-19-0 | 2.5mg | $535 | 2021-12-16 | Buy |
KDU691 Chemical Properties,Uses,Production
Description
KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC50 value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC50 = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.
Uses
KDU691, is a PI4K inhibitor.
KDU691 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |