SANGUINARINE
- CAS No.
- 2447-54-3
- Chemical Name:
- SANGUINARINE
- Synonyms
- C06162;Sangrovit;SANGUINARIN;SANGUINARINE;Free sanguinarine;PSEUDOCHELERYTHRINE;SANGUINARINE, 40+% BY UV;SANGUINARINE, 98+% BY HPLC;dimethylenedioxybenzphenanthridine;Sanguinarine/Macleaya cordata extract
- CBNumber:
- CB3395590
- Molecular Formula:
- C20H14NO4+
- Molecular Weight:
- 332.33
- MDL Number:
- MFCD00064925
- MOL File:
- 2447-54-3.mol
| Melting point | 205-215°C |
|---|---|
| Boiling point | 483.53°C (rough estimate) |
| Density | 1.3463 (rough estimate) |
| refractive index | 1.5180 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| color | White |
| LogP | -0.653 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | AV9VK043SS |
SANGUINARINE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FS40153 | Sanguinarine | 2447-54-3 | 10mg | $50 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS40153 | Sanguinarine | 2447-54-3 | 25mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | N1338 | Sanguinarine | 2447-54-3 | 20mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS40153 | Sanguinarine | 2447-54-3 | 50mg | $150 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594267 | Sanguinarine | 2447-54-3 | 20mg | $306 | 2021-12-16 | Buy |
SANGUINARINE Chemical Properties,Uses,Production
Description
Sanguinarine, a DNA intercalator extracted from the bloodroot plant of the poppy family, was used by Native Americans for warts and as a blood purifier. In modern use, although banned by the FDA for its association with epidemic dropsy and other toxic effects, it has shown potential as a treatment for cancer, with modes of action including inhibition of metastasis and angiogenesis, and promotion of apoptosis. It also has anti-inflammatory, anti-oxidant, and anti-microbial properties, and several applications in veterinary medicine.
Sources
https://en.wikipedia.org/wiki/Sanguinarine
https://pubchem.ncbi.nlm.nih.gov/compound/sanguinarine#section=Human-Metabolite-Information
https://www.essense-of-life.com/healthtopics/A-513/Sanguinarine-Health-Topic.html
https://www.caymanchem.com/product/16951
https://www.sciencedirect.com/topics/nursing-and-health-professions/sanguinarine
Description
A naphthoisoquinoline alkaloid, this base occurs in the roots of Chelidonium majus L., Glaucium fimbrilligerum and Sanguinaria canadensis L. The alkaloid was stated by Schmidt, Konig and Tietz to crystallize from EtOH or AcOEt as colourless needles, m.p. 213°C but this low melting point was found to be due to the presence of chelerythrine as an impurity. Once this is removed as the pseudocyanide, the base crystallizes from Et20 and has the above melting point or 242-3°C on slow heating. Obtained from EtOH it forms the alcoholate, m.p. 195-7°C. The hydrochloride forms long, slender, bloodred needles. On distillation with Zn dust, the alkaloid furnishes a-naphthaphenanthridine and the structure given above has been further confirmed by synthesis.
Uses
Sanguinarium induces HO-1 expression thus inhibiting MMP-9 and COX-2 expression in TPA-induced breast cancer cells.
Definition
Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadendid. Limited available evidence indicates that it may be used to prevent and treat UV-induced skin damage. Specifically, topical application of sanguinarine on the skin of SKH-1 hairless mice before or after UVB irradiation resulted in significantly lower UVB-mediated skin edema, skin hyperplasia and infiltration of leukocytes, and markers of oxidative stress (e.g., H2O2).
References
Dana., Mag. Pharm., 23, 125 (1829)
Bruchhausen, Bersch., Ber., 63, 2520 (1930)
Spath, Kuffner., ibid, 64, 370, 1123, 2034 (1931)
Synthesis:
Dyke, Moon, Sainsbury., Tetrahedron Lett., 3933 (1968)
SANGUINARINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +8618374838656 | sales@staherb.cn | China | 1025 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 371 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9342 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
View Lastest Price from SANGUINARINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | Sanguinarine
2447-54-3
|
US $0.00-0.00 / kg | 1kg | 99 | 5000 tons | Shanghai Affida new material science and technology center | |
 |
2024-04-12 | Plumepoppy Extract
2447-54-3
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-02-24 | Sanguinarine
2447-54-3
|
US $0.00 / mg | 20mg | ≥98%(HPLC | 100 g | Shanghai Standard Technology Co., Ltd. |
-
- Sanguinarine
2447-54-3
- US $0.00-0.00 / kg
- 99
- Shanghai Affida new material science and technology center
-
- Plumepoppy Extract
2447-54-3
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Sanguinarine
2447-54-3
- US $0.00 / mg
- ≥98%(HPLC
- Shanghai Standard Technology Co., Ltd.
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