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PFE-360
- CAS No.
- 1527475-61-1
- Chemical Name:
- PFE-360
- Synonyms
- PFE-360;PF-06685360;1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-;PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2
- CBNumber:
- CB35419811
- Molecular Formula:
- C16H16N6O
- Molecular Weight:
- 308.34
- MDL Number:
- MOL File:
- 1527475-61-1.mol
Last updated:2023-09-20 16:43:00
PFE-360 Chemical Properties,Uses,Production
Description
PFE-360 (PF-06685360) is a poten and elective inhibitor of LRRK2 kinase.
in vitro
PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment potently decreases the LRRK2-pSer935/total LRRK2 ratio, with no significant adverse effects.
animal Model: Female Sprague Dawley rats (NTac:SD) weighed 225-250 g.
Dosage: 4 mg/kg and 7.5 mg/kg (pharmacokinetics and pharmacodynamics).
Administration: Orally BID for 10-12 weeks.
Result: The LRRK2-pSer935/total LRRK2 ratio was significantly decreased at both 1 h and 12 h after dosing.
The terminal bodyweights exhibited no significant changes.
PFE-360 Preparation Products And Raw materials
Raw materials
Preparation Products
PFE-360 Suppliers
Global( 20)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| NINGBOBENKANGJS PHARMTECHCO., LTD | +8615990591583 15990591583 | CHINA | 2029 | 58 | |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 360 | 55 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | xiaoyangw@gmail.com | China | 2129 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. | 15990591583 | China | 5564 | 58 | |
| Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1953 | 58 |
PFE-360
PF-06685360
1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2
1527475-61-1