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Methyl (4-bromobenzoyl)-L-cysteinate
- CAS No.
- 1947408-74-3
- Chemical Name:
- Methyl (4-bromobenzoyl)-L-cysteinate
- Synonyms
- Methyl (4-bromobenzoyl)-L-cysteinate;L-Cysteine, N-(4-bromobenzoyl)-, methyl ester;pharmacophore,inhibit,Cysteine thiol probe,products,enone-based,chromophore,thiol-based,electrophilic,Inhibitor,l-cystine,Natural
- CBNumber:
- CB35542274
- Molecular Formula:
- C11H12BrNO3S
- Molecular Weight:
- 318.19
- MDL Number:
- MOL File:
- 1947408-74-3.mol
Last updated:2023-09-20 16:43:00
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Methyl (4-bromobenzoyl)-L-cysteinate Chemical Properties,Uses,Production
Uses
Methyl (4-bromobenzoyl)-L-cysteinate is a chemoselective thiol probe for detection of electrophilic metabolites. As it is often difficult to isolate low-abundance natural products from extracts, metabolities with bioactivity or therapeutic potential may be missed. Castro-Falcón, et al developed a reactivity-guided approach using thiolate probes to discover electrophilic natural products - a cysteine-based probe and thiophenol-based probe. Both consist of
- A chemoselective reagent for covalent reactivity with a pharmacophore,
- A conspicuous UV/VIS or mass spectrometric (MS) tag,
- A linker between the tag and reagent. Methyl (4-bromobenzoyl)-L-cysteinate contains a bromine MS tag and phenyl bromide UV tag that was demonstrated to chemoselectively label enone-, β-lactam-, and β-lactone-based natural products.
Complementarily, a thiophenol probe (cat# 125237) with a chlorine MS tag and phenyl chloride UV tag labeled epoxide-based natural products. These probes can be used in diverse extracts (bacterial, fungal, plant) to chemically faciliate access to high-value metabolites.
Methyl (4-bromobenzoyl)-L-cysteinate Preparation Products And Raw materials
Raw materials
Preparation Products
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Methyl (4-bromobenzoyl)-L-cysteinate
pharmacophore,inhibit,Cysteine thiol probe,products,enone-based,chromophore,thiol-based,electrophilic,Inhibitor,l-cystine,Natural
L-Cysteine, N-(4-bromobenzoyl)-, methyl ester
1947408-74-3