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ASN007

ASN007 structure

CAS No.: 2055597-12-9

Chemical Name:: ASN007

Synonyms: ASN007;ERK-IN-3;ASN007 free base;ASN007（ERAS 007）;ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-

CBNumber:: CB38080025

Molecular Formula:: C22H25ClFN7O2

Molecular Weight:: 473.93

MDL Number:

MOL File:: 2055597-12-9.mol

Last updated:2023-09-20 16:43:00

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ASN007 Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (527.50 mM; Need ultrasonic)
pka	12.73±0.46(Predicted)

ASN007 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0131841	ERK-IN-3 98.44%	2055597-12-9	5mg	$150	2021-12-16	Buy
ChemScene	CS-0131841	ERK-IN-3 98.44%	2055597-12-9	10mg	$250	2021-12-16	Buy
ChemScene	CS-0131841	ERK-IN-3 98.44%	2055597-12-9	25mg	$550	2021-12-16	Buy
ChemScene	CS-0131841	ERK-IN-3 98.44%	2055597-12-9	50mg	$950	2021-12-16	Buy
ChemScene	CS-0131841	ERK-IN-3 98.44%	2055597-12-9	100mg	$1550	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0131841	5mg	$150	Buy
CS-0131841	10mg	$250	Buy
CS-0131841	25mg	$550	Buy
CS-0131841	50mg	$950	Buy
CS-0131841	100mg	$1550	Buy

ASN007 Chemical Properties,Uses,Production

Biological Activity

ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations[1]. ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].

References

[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

ASN007 Preparation Products And Raw materials

Raw materials

Preparation Products

ASN007 Suppliers

Global( 21)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238 17702719238	sales@sun-shinechem.com	China	918	64
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3423	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Kaixin Chemical (Hong Kong) Limited	010-88886666-01 13112345678	loyson@tcypharm.com	China	595	55
Amatek Scientific Co. Ltd.	0512-56316828	info@amateksci.com	China	28821	58
Wuhan Sun-shine Bio-technology Corporation Limited	+86-027-6552-2453	sales@sun-shinechem.com	China	727	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58

Supplier	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	64
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
ShangHai Biochempartner Co.,Ltd	62
Kaixin Chemical (Hong Kong) Limited	55
Amatek Scientific Co. Ltd.	58
Wuhan Sun-shine Bio-technology Corporation Limited	58
DC Chemicals	58

ASN007 Spectrum

ASN007(2055597-12-9)¹HNMR

ASN007 ASN007 free base N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide ERK-IN-3 ASN007（ERAS 007） ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3 1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]- 2055597-12-9