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ChemicalBook >> CAS DataBase List >>Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Structure
Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- structure
CAS No.
1923844-48-7
Chemical Name:
Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-
Synonyms
BMS-986242;Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]-;glucuronidation,potent,Indoleamine 2,3-Dioxygenase (IDO),cancer,Inhibitor,BMS 986242,inhibit,BMS-986242,active,selective,orally
CBNumber:
CB39008426
Molecular Formula:
C24H24ClFN2O
Molecular Weight:
410.91
MDL Number:
MFCD34474214
MOL File:
1923844-48-7.mol
Last updated:2023-05-21 10:59:17
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Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Properties

Boiling point 593.0±40.0 °C(Predicted)
Density 1.228±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (608.41 mM; Need ultrasonic)
pka 14.09±0.46(Predicted)

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Chemical Properties,Uses,Production

Biological Activity

BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer[1]. BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ～20 % max inhibition)[1]. BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses[1].

References

[1]. Cherney EC, et al. Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1. ACS Med Chem Lett. 2021;12(2):288-294. Published 2021 Jan 28.

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- Suppliers

Global( 19)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4604 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4153 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9767 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 9038 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29796 68
Fujian boshi pharmaceutical technology co. LTD 18120708884 393612455@qq.com China 255 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Fujian boshi pharmaceutical technology co. LTD 58
Benzamide, 4-chloro-N-[(1R)-1-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]ethyl]- BMS-986242 glucuronidation,potent,Indoleamine 2,3-Dioxygenase (IDO),cancer,Inhibitor,BMS 986242,inhibit,BMS-986242,active,selective,orally 1923844-48-7