ChemicalBook >> CAS DataBase List >>L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-

L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-

L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- structure

CAS No.: 2245195-67-7

Chemical Name:: L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-

Synonyms: HeE1-2Tyr;L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-;HeE12Tyr,Nile,West,SARS-CoV,HeE1 2Tyr,SARS coronavirus,RdRp,HeE1-2Tyr,inhibit,HeE-1-2Tyr,flavivirus,Dengue,Inhibitor

CBNumber:: CB39799276

Molecular Formula:: C33H30N2O6S

Molecular Weight:: 582.67

MDL Number:

MOL File:: 2245195-67-7.mol

Last updated:2023-05-21 10:59:17

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L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Properties

Boiling point	842.3±65.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (171.62 mM; Need ultrasonic)
pka	3.06±0.10(Predicted)

L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Chemical Properties,Uses,Production

Biological Activity

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro[1][2]. HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM[1].Additionally, upon infection of human HEK 293 cells (CC50 of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 μM[1]. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].

References

[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.

L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3423	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	359	55
Kaifeng Mingren Pharmaceutical Co.,LTD	0371-65741762	sales@hasunny.com	China	2380	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9180	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai Beckham Medical Technology Co., Ltd	55
Kaifeng Mingren Pharmaceutical Co.,LTD	58
TargetMol Chemicals Inc.	58
RD International Technology Co., Limited	58

L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- HeE1-2Tyr HeE12Tyr,Nile,West,SARS-CoV,HeE1 2Tyr,SARS coronavirus,RdRp,HeE1-2Tyr,inhibit,HeE-1-2Tyr,flavivirus,Dengue,Inhibitor 2245195-67-7