Dianhydrogalactitol
- CAS No.
- 23261-20-3
- Chemical Name:
- Dianhydrogalactitol
- Synonyms
- 1,2:5,6-Dianhydrogalactitol;VAL-083;VAL083;VAL 083;NSC-132313;Dulcitol diepoxide;Dianhydrodulcitolum;Dianhydrogalactitol;5,6-Diepoxydulcitol;1,2:5,6-Diepoxydulcitol
- CBNumber:
- CB41016710
- Molecular Formula:
- C6H10O4
- Molecular Weight:
- 146.14
- MDL Number:
- MFCD01725532
- MOL File:
- 23261-20-3.mol
- MSDS File:
- SDS
| Melting point | 96.5-98.5 °C |
|---|---|
| Boiling point | 185.74°C (rough estimate) |
| Density | 1.567 |
| refractive index | 1.4310 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 13.53±0.20(Predicted) |
| FDA UNII | 4S465RYF7M |
| NCI Drug Dictionary | dianhydrogalactitol |
Dianhydrogalactitol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3333 | Dianhydrogalactitol ≥95% (HPLC) | 23261-20-3 | 5MG | $88.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3333 | Dianhydrogalactitol ≥95% (HPLC) | 23261-20-3 | 25MG | $357 | 2024-03-01 | Buy |
| TRC | D720515 | DulcitolDiepoxide | 23261-20-3 | 10mg | $150 | 2021-12-16 | Buy |
| Usbiological | 293253 | 1,2:5,6-Dianhydrogalactitol | 23261-20-3 | 100mg | $602 | 2021-12-16 | Buy |
| ChemScene | CS-1358 | VAL-083 | 23261-20-3 | 10mg | $300 | 2021-12-16 | Buy |
Dianhydrogalactitol Chemical Properties,Uses,Production
Uses
Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.
Biological Activity
val-083 is a bi-functional alkylating agent, with potential antitumor activity.val-083 can cross the blood brain barrier and appears to be selective for tumor cells. val-083 alkylates and crosslinks dna which ultimately inhibit the proliferation of cancer cells. val-083 does not show cross-resistance to other conventional chemotherapeutic agents. the half-life of val-083 in the brain is long. val-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.
in vitro
VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h.
in vivo
VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. It (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.
target
DNA
References
http://www. delmarpharma.com/product_development_programs/val083/
Dianhydrogalactitol Preparation Products And Raw materials
Raw materials
Preparation Products
Dianhydrogalactitol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28149 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from Dianhydrogalactitol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-06 | Dianhydrodulcitol USP/EP/BP | US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
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- Dianhydrodulcitol USP/EP/BP
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited