Bulaquine
- CAS No.
- 79781-00-3
- Chemical Name:
- Bulaquine
- Synonyms
- Bulaquine;CDRI-80/53;aablaquine;compound 80-53;N-[(3-Acetyl-4,5-dihydrofuran)-2-yl]-N'-(6-methoxy-8-quinolinyl)-1,4-pentanediamine;1-[4,5-Dihydro-2-[[4-[(6-methoxyquinoline-8-yl)amino]pentyl]amino]furan-3-yl]ethanone;2(3H)-Furanone, dihydro-3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-
- CBNumber:
- CB41344929
- Molecular Formula:
- C21H27N3O3
- Molecular Weight:
- 369.46
- MDL Number:
- MFCD00890219
- MOL File:
- 79781-00-3.mol
| Boiling point | 616.7±55.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| pka | 5.60±0.20(Predicted) |
| FDA UNII | TSQ6U39Q3G |
Bulaquine Chemical Properties,Uses,Production
Description
Bulaquine is a derivative of primaquine that was introduced in India in combination with chloroquine as a treatment against malaria. The compound is prepared by condensation of primaquine with 3-acetyl-y-butyrolactone in presence of a catalytic amount of base. Bulaquine kills the latent tissue stage (hypnozoites) of the parasite Plasmodium vivax accumulated in the liver and responsible for relapses. Its efficient anti-relapse activity was demonstrated against sporozoite induced Plasmodium cynomolgi infection in rhesus monkey. Bulaquine is safer than primaquine, the preceding candidate against malaria relapse. Although it is stable at pH 7-8, bulaquine is hydrolyzed to primaquine under acidic conditions.
Originator
CDRI (India)
Uses
Bulaquine is anti-malarial drug.
Definition
ChEBI: Bulaquine is an aminoquinoline.
brand name
Aablaquin
Bulaquine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 18080489829 | 3004654993@qq.com | China | 9209 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |