Flavoxate hydrochloride
- CAS No.
- 3717-88-2
- Chemical Name:
- Flavoxate hydrochloride
- Synonyms
- DW-61;Urispas;genurin;spasuret;bladderon;nsc-114649;REC-7-0040;FLAVOXATE HCL;FLAVOMYCINPREMIX;flaroxatehydrochloride
- CBNumber:
- CB4243322
- Molecular Formula:
- C24H26ClNO4
- Molecular Weight:
- 427.92
- MDL Number:
- MFCD00072099
- MOL File:
- 3717-88-2.mol
- MSDS File:
- SDS
| Melting point | 232-234°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: ~6.6 mg/mL |
| form | solid |
| color | white |
| InChI | InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H |
| InChIKey | XOEVKNFZUQEERE-UHFFFAOYSA-N |
| SMILES | C12OC(=C(C)C(=O)C=1C=CC=C2C(=O)OCCN1CCCCC1)C1C=CC=CC=1.Cl |
| CAS DataBase Reference | 3717-88-2(CAS DataBase Reference) |
| FDA UNII | 9C05J6089W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H335 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ2450000 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 i.v. in rats: 27.4 mg/kg (Cazzulani) | |||||||||
| NFPA 704 |
|
Flavoxate hydrochloride price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3316 | Flavoxate hydrochloride certified reference material, pharmaceutical secondary standard | 3717-88-2 | 500MG | $208 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP571 | Flavoxate hydrochloride British Pharmacopoeia (BP) Reference Standard | 3717-88-2 | 100MG | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1270708 | Flavoxate hydrochloride United States Pharmacopeia (USP) Reference Standard | 3717-88-2 | 200mg | $393 | 2024-03-01 | Buy |
| Sigma-Aldrich | F8304 | Flavoxate hydrochloride ≥98% (HPLC), solid | 3717-88-2 | 10mg | $186 | 2022-05-15 | Buy |
| TCI Chemical | F0717 | Flavoxate Hydrochloride >98.0%(HPLC)(T) | 3717-88-2 | 5g | $88 | 2024-03-01 | Buy |
Flavoxate hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Flavoxate hydrochloride is Crystalline Solid
Originator
Urispas,SKF,US,1971
Uses
Smooth muscle relaxant. Used as antispasmodic; in treatment of urinary incontinence.
Uses
Antispasmodic;Phosphodiesterase inhibitor
Definition
ChEBI: The hydrochloride salt of flavoxate.
Manufacturing Process
A mixture of 13.3 grams of anhydrous aluminum chloride and 100 ml of
carbon disulfide is added to 19.4 grams of 2-propionyloxybenzoic acid
(prepared from the reaction of propionyl chloride and 2-hydroxybenzoic acid).
After an initial evolution of hydrogen chloride, the solvent is removed by
distillation and the mixture is heated at 150° to 160°C for 4 hours. The cooled
reaction mixture is treated with ice and hydrochloric acid and the product, 2-
hydroxy-3-carboxypropiophenone, is obtained from the oily residue by
distillation in vacuo.
A mixture of 1.9 grams of 2-hydroxy-3-carboxypropiophenone, 5.0 grams of
sodium benzoate and 20.0 grams of benzoic anhydride is heated at 180° to
190°C for 6 hours. A solution of 15.0 grams of potassium hydroxide in 50 ml
of ethanol and 20 ml of water is added and refluxed for 1 hour. The mixture is
evaporated and the residue after addition of water yields 3-methylflavone-8-
carboxylic acid.
To a suspension of 12.0 grams of 3-methylflavone-8-carboxylic acid in 200 ml
of anhydrous benzene is added 10.0 grams of thionyl chloride. The mixture is
refluxed for 2 hours during which the suspended solid goes into solution. The
solvent is completely removed by distillation, the residue extracted with
benzene and the extract evaporated to dryness. The product, 3-
methylflavone-8-carboxylic acid chloride, is recrystallized from ligroin to give
crystals melting at 155° to 156°C.
To 11.0 grams of 3-methylflavone-8-carboxylic acid chloride dissolved in 150
ml of anhydrous benzene is added at room temperature 4.8 grams of
piperidinoethanol and the mixture refluxed for 2 to 3 hours. The separated
solid is filtered, washed with benzene and dried. The product, piperidinoethyl
3-methylflavone-8-carboxylate hydrochloride is obtained as a colorless
crystalline solid, MP 232° to 234°C, (from US Patent 2,921,070).
brand name
Urispas (Ortho-McNeil).
Therapeutic Function
Spasmolytic
Side effects
The following adverse reactions have been observed, but there are not enough data to support an estimate of their frequency.
Gastrointestinal: Nausea, vomiting, dry mouth.
CNS: Vertigo, headache, mental confusion, especially in the elderly, drowsiness, nervousness.
Hematologic: Leukopenia (one case which was reversible upon discontinuation of the drug).
Cardiovascular: Tachycardia and palpitation.
Allergic: Urticaria and other dermatoses, eosinophilia and hyperpyrexia.
Ophthalmic: Increased ocular tension, blurred vision, disturbance in eye accommodation.
Renal: Dysuria.
Veterinary Drugs and Treatments
Flovoxate may be considered for treating dogs with detrusor hyperspasticity (hyperactive bladder, urge incontinence).
Pharmacology
Flavoxate hydrochloride counteracts smooth muscle spasm of the urinary tract and exerts its effect directly on the muscle. In a single study of 11 normal male subjects, the time to onset of action was 55 minutes. The peak effect was observed at 112 minutes. 57% of the flavoxate hydrochloride was excreted in the urine within 24 hours.
Flavoxate hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 | admin@hbsaisier.cn | China | 931 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
View Lastest Price from Flavoxate hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Flavoxate Hydrochloride
3717-88-2
|
US $60.00 / kg | 1kg | 99.9% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-12 | Flavoxate hydrochloride
3717-88-2
|
US $6.00 / KG | 25KG | More than 99% | 2000KG/Month | Hebei Saisier Technology Co., LTD | |
 |
2024-01-23 | Flavoxate hydrochloride
3717-88-2
|
US $110.00-90.00 / kilogram | 1kilogram | 99% | 10 tons/per week | Henan Tengmao Chemical Technology Co. LTD |
-
- Flavoxate Hydrochloride
3717-88-2
- US $60.00 / kg
- 99.9%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Flavoxate hydrochloride
3717-88-2
- US $6.00 / KG
- More than 99%
- Hebei Saisier Technology Co., LTD
-
- Flavoxate hydrochloride
3717-88-2
- US $110.00-90.00 / kilogram
- 99%
- Henan Tengmao Chemical Technology Co. LTD