GLYX 13
- CAS No.
- 117928-94-6
- Chemical Name:
- GLYX 13
- Synonyms
- GLYX 13;GIYX-13;CS-1640;Rapastinel;TPPT-amide;GLYX 13 TFA;UNII-6A1X56B95E;NRX-1074 GLYX-13;GLYX13(Rapastinel);Rapastinel(GLYX-13)
- CBNumber:
- CB42518800
- Molecular Formula:
- C18H31N5O6
- Molecular Weight:
- 413.47
- MDL Number:
- MFCD12912477
- MOL File:
- 117928-94-6.mol
- MSDS File:
- SDS
| Boiling point | 844.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.370±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml |
| pka | 12.26±0.45(Predicted) |
| form | powder |
| color | white to tan |
| Water Solubility | Soluble to 2 mg/ml in water |
| FDA UNII | 6A1X56B95E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
GLYX 13 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0109 | GLYX-13 trifluoroacetate ≥98% (HPLC) | 117928-94-6 | 1mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 21385 | GLYX 13 ≥98% | 117928-94-6 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 21385 | GLYX 13 ≥98% | 117928-94-6 | 5mg | $426 | 2024-03-01 | Buy |
| Tocris | 3406 | GLYX13 | 117928-94-6 | 1 | $150 | 2021-12-16 | Buy |
| TRC | G650020 | GLYX-13 | 117928-94-6 | 1mg | $60 | 2021-12-16 | Buy |
GLYX 13 Chemical Properties,Uses,Production
Uses
GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder.
Uses
Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
Uses
GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.
Biochem/physiol Actions
GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.
storage
Store at -20°C
GLYX 13 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 | sales2@qschem-pharma.com | China | 46 | 58 |
| Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1125 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 274 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
View Lastest Price from GLYX 13 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-20 | GLYX-13
117928-94-6
|
US $30.00 / box | 1box | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-05-15 | GLYX 13
117928-94-6
|
US $28.00 / box | 1box | 99% | 20000 | Shanghai Getian Industrial Co., LTD | |
 |
2024-04-16 | GLYX-13
117928-94-6
|
US $0.00 / g | 1g | 99% | 100kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |