KD 5170
- CAS No.
- 940943-37-3
- Chemical Name:
- KD 5170
- Synonyms
- KD 5170;KD5170; KD-5170;S-(2-(6-(4-(3-(DiMethylaMino)propoxy)phenylsulfonaMido)pyridin-3-yl)-2-oxoethyl) ethanethioate;S-(2-{6-[({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)amino]-3-p Yridinyl}-2-oxoethyl) Ethanethioate;Ethanethioic acid, S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester
- CBNumber:
- CB42538280
- Molecular Formula:
- C20H25N3O5S2
- Molecular Weight:
- 451.56
- MDL Number:
- MOL File:
- 940943-37-3.mol
| Boiling point | 637.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.310±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ≥21.2 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 9.29±0.28(Predicted) |
| FDA UNII | 26UQK478QL |
KD 5170 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13214 | KD 5170 ≥98% | 940943-37-3 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 13214 | KD 5170 ≥98% | 940943-37-3 | 5mg | $128 | 2024-03-01 | Buy |
| Cayman Chemical | 13214 | KD 5170 ≥98% | 940943-37-3 | 10mg | $202 | 2024-03-01 | Buy |
| Cayman Chemical | 13214 | KD 5170 ≥98% | 940943-37-3 | 25mg | $465 | 2024-03-01 | Buy |
| Usbiological | 255590 | KD 5170 | 940943-37-3 | 10mg | $466 | 2021-12-16 | Buy |
KD 5170 Chemical Properties,Uses,Production
Description
KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively). It exhibits broad spectrum antitumor activity in vitro and in vivo. KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.
References
[1]. hassig ca, symons kt, guo x, et al. kd5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. mol cancer ther, 2008, 7(5): 1054-1065.
[2]. payne je, bonnefous c, hassig ca, et al. identification of kd5170: a novel mercaptoketone-based histone deacetylase inhibitor. bioorg med chem lett, 2008, 18(23): 6093-6096.
[3]. feng r, ma h, hassig ca, et al. kd5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by dna damage and mitochondrial signaling. mol cancer ther, 2008, 7(6): 1494-1505.
KD 5170 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 028-85114309 15881143215 | liangli@happysyn.com | China | 1734 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
