A 582941
- CAS No.
- 848591-90-2
- Chemical Name:
- A 582941
- Synonyms
- A 582941;A 582941; A582941;A-582941 dihydrochloride;Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole;2-Methyl-5-(6-phenylpyridazin-3-yl)octahydropyrrolo[3,4-c]pyrrole dihydrochloride;Pyrrolo[3,4-c]pyrrole, octahydro-2-Methyl-5-(6-phenyl-3-pyridazinyl)-, dihydrochloride;Pyrrolo[3,4-c]pyrrole, octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-, hydrochloride (1:2);(3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole;2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole:dihydrochloride;Serotonin Receptor,psychiatric,5-HT3,deficits,Inhibitor,A582941 dihydrochloride,Nicotinic acetylcholine receptors,neurodegenerative,nAChR,A582941,5-hydroxytryptamine Receptor,partial,cognitive,A 582941 dihydrochloride,A-582941,5-HT Receptor,inhibit
- CBNumber:
- CB42561068
- Molecular Formula:
- C17H21ClN4
- Molecular Weight:
- 316.83
- MDL Number:
- MOL File:
- 848591-90-2.mol
| storage temp. | Desiccate at RT |
|---|---|
| solubility | <28.04mg/ml in DMSO; <14.02mg/ml in 1eq. HCl |
| form | solid |
| color | White |
| FDA UNII | T05UG0DBFB |
A 582941 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4341 | A582941 ≥98%(HPLC) | 848591-90-2 | 50 | $713 | 2021-12-16 | Buy |
| Tocris | 4341 | A582941 ≥98%(HPLC) | 848591-90-2 | 10 | $175 | 2021-12-16 | Buy |
| TRC | A965358 | A582941 | 848591-90-2 | 5mg | $440 | 2021-12-16 | Buy |
| ApexBio Technology | B7652 | A582941 | 848591-90-2 | 10mg | $339 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001288 | OCTAHYDRO-2-METHYL-5-(6-PHENYL-3-PYRIDAZINYL)PYRROLO[3,4-C]PYRROLE 95.00% | 848591-90-2 | 10MG | $756.53 | 2021-12-16 | Buy |
A 582941 Chemical Properties,Uses,Production
Uses
A 582941 has been shown to provide glycogen synthase kinase-3β activation and α7 nicotinic receptors in Aβ1-42-induced tau phosphorylation in PC12 cells, which is useful in neurodegeneration associated with Alzheimer''s disease research.
Biological Activity
a 582941 is a highly selective partial agonist of α7 nicotinic acetylcholine receptors (nachrs), with an ec50 value of 4260 nm to human α7 nachrs [1].nachrs are a family of pentameric ligand-gated ion channels. they are derived from multiple α (α2-α10) and β (β2-β4) subunit genes. α7 nachr receptor exhibits higher ca2+ permeability than other nachr combinations. these receptors modulate the release of multiple neurotransmitters, including acetylcholine (ach), glutamate, and gaba [1].in flipr, a 582941 did not activate recombinant heteromeric nachrs (α4β2, α3β2, α3β4, or α4β4) according to ca2+ dynamics results. in imr-32 cells expressing native human α3β4 nachrs, a 582941 did not produce an agonist effect (with an efficacy less than 20% at concentrations up to 100,000 nm). in xenopus oocytes expressing an α9α10 nachr construct, a 582941 at concentrations up to 100,000 nm did not evoke currents. with respect to nachrs, a 582941 activated only the homomeric α7 subtype [1].in a rat model of short-term memory based on olfactory cues, saline-treated adults used investigation times during the second session nearly equal to the first session, exhibiting little recognition of the juvenile. treatment with a 582941 in adult rats resulted in a dose-related reduction in the exploration time during the second session compared with the first session, exhibiting improved recognition of the juvenile [1].
storage
Desiccate at RT
References
[1]. tietje kr, anderson dj, bitner rs, et al. preclinical characterization of a-582941: a novel α7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. cns neuroscience & therapeutics, 2008, 14(1): 65-82.
A 582941 Preparation Products And Raw materials
Raw materials
Preparation Products
A 582941 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4981 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 61720 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| AdooQ BioScience, LLC | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 55 |
| BOC Sciences | 65 |
| Absin Bioscience Inc. | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| cjbscvictory | 58 |
| Bide Pharmatech Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |