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SC 66

SC 66 structure

CAS No.: 871361-88-5

Chemical Name:: SC 66

Synonyms: SC 66;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis

CBNumber:: CB42565930

Molecular Formula:: C18H16N2O

Molecular Weight:: 276.33

MDL Number:: MFCD05025493

MOL File:: 871361-88-5.mol

Last updated:2023-06-30 15:45:59

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SC 66 Properties

storage temp.	Sealed in dry,2-8°C
solubility	DMSO: ≥5mg/mL (warmed)
form	powder
color	faint yellow to dark yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3

SC 66 price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10876	SC-66 ≥98%	871361-88-5	5mg	$38	2024-03-01	Buy
Cayman Chemical	10876	SC-66 ≥98%	871361-88-5	10mg	$71	2024-03-01	Buy
Cayman Chemical	10876	SC-66 ≥98%	871361-88-5	25mg	$166	2024-03-01	Buy
Cayman Chemical	10876	SC-66 ≥98%	871361-88-5	100mg	$510	2024-03-01	Buy
Tocris	4398	SC66 ≥98%(HPLC)	871361-88-5	50	$378	2021-12-16	Buy

Product number	Packaging	Price	Buy
10876	5mg	$38	Buy
10876	10mg	$71	Buy
10876	25mg	$166	Buy
10876	100mg	$510	Buy
4398	50	$378	Buy

SC 66 Chemical Properties,Uses,Production

Description

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP₃) or phosphatidylinositol-3,4-bisphosphate (PIP₂). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.

Uses

SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

storage

-20°C

SC 66 Preparation Products And Raw materials

Raw materials

Preparation Products

SC 66 Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58

View Lastest Price from SC 66 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-24	SC 66 871361-88-5	US $1.00 / g	1g	99%	20kg	Career Henan Chemical Co

SC 66
871361-88-5
US $1.00 / g
99%
Career Henan Chemical Co

871361-88-5(SC 66)Related Search:

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 57461A α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

SC 66 Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone CS-2480 SC66;SC 66 (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis 871361-88-5