LH 21
- CAS No.
- 611207-11-5
- Chemical Name:
- LH 21
- Synonyms
- LH 21;LH21; LH 21;LH 21 Exclusive;1H-1,2,4-Triazole, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-
- CBNumber:
- CB42591597
- Molecular Formula:
- C20H20Cl3N3
- Molecular Weight:
- 408.75
- MDL Number:
- MOL File:
- 611207-11-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
NFPA 704 |
|
LH 21 price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 13453 | LH 21 ≥98% | 611207-11-5 | 1mg | $60 | 2024-03-01 | Buy |
Cayman Chemical | 13453 | LH 21 ≥98% | 611207-11-5 | 5mg | $259 | 2024-03-01 | Buy |
Cayman Chemical | 13453 | LH 21 ≥98% | 611207-11-5 | 10mg | $457 | 2024-03-01 | Buy |
ApexBio Technology | C3642 | LH21 | 611207-11-5 | 10mg | $521 | 2021-12-16 | Buy |
AK Scientific | 5792CR | 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1,2,4-triazole | 611207-11-5 | 10mg | $607 | 2021-12-16 | Buy |
LH 21 Chemical Properties,Uses,Production
Description
LH 21 is a 1,2,4-
in vitro
previous study showed that lh-21 was able to inhibit the binding of [3h]cp55940 to cloned human and rat cb1 receptors with ic50 values of 631 ±98 nm, and 690 ± 41 nm, respectively. lh-21 acted as an inverse agonist in a camp functional assay using cultured cells expressing human, rat or mouse cb1 receptor. in addition, in cho cells overexpressing cb1, lh-21 was able to elevate camp, further confirming that lh-21 acted as an inverse agonist of cb1 in this model [1].
in vivo
animal study showed that when given acutely lh-21 could decrease food intake and enhance the anorectic actions of oleoylethanolamide, a feeding suppressant lipid acting on peripheral sensory terminals in a similar way as rimonabant. however, unlike rimonabant, chronic administration of lh-21 at 3 mg/kg was able to reduce feeding but did not improve hypercholesterolaemia or hypertriglyceridaemia; nor did it reduce liver fat deposits in zucker rats [2].
IC 50
631 ±98 and 690 ± 41 nm for human and rat cb1 receptors, respectively
References
[1] chen, r. z.,frassetto, a.,lao, j.z., et al. pharmacological evaluation of lh-12, a newly discovered molecule that binds to cannabinoid cb1 receptor. european journal of pharmacology 584, 338-342 (2008).
[2] pavón, f. j.,serrano, a.,pérez-valero, v., et al. central versus peripheral antagonism of cannabinoid cb1 receptor in obesity: effects of lh-21, a peripherally acting neutral cannabinoid receptor antagonist, in zucker rats. journal of neuroendocrinology 20, 116-123 (2008).
LH 21 Preparation Products And Raw materials
Raw materials
Preparation Products
LH 21 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 811 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |