ChemicalBook >> CAS DataBase List >>6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
![6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Structure](CAS/GIF/288628-05-7.gif)
- CAS No.
- 288628-05-7
- Chemical Name:
- 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
- Synonyms
- STX 64;ST-64667;BN 83495;STX64667;STX 64667;Irosustat;Irosustat(STX64);COUMATE. Irosustat.;DSLPMJSGSBLWRE-UHFFFAOYSA-N;STX64 - BN83495 | Irosustat | 667 Coumate
- CBNumber:
- CB42597564
- Molecular Formula:
- C14H15NO5S
- Molecular Weight:
- 309.34
- MDL Number:
- MFCD12912443
- MOL File:
- 288628-05-7.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 170.1-173.4 °C |
|---|---|
| Boiling point | 544.1±60.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| form | white powder |
| pka | 8.26±0.70(Predicted) |
| FDA UNII | 366037O6O7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| WGK Germany | 3 |
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S1950 | STX64 ≥98% (HPLC) | 288628-05-7 | 5mg | $211 | 2024-03-01 | Buy |
| Sigma-Aldrich | S1950 | STX64 ≥98% (HPLC) | 288628-05-7 | 25mg | $662 | 2024-03-01 | Buy |
| TRC | S687208 | STX64 | 288628-05-7 | 2.5mg | $275 | 2021-12-16 | Buy |
| Axon Medchem | Axon2892 | STX64-BN83495|Irosustat|667Coumate 99% | 288628-05-7 | 5mg | $99 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005149 | BN-83495 95.00% | 288628-05-7 | 5MG | $728 | 2021-12-16 | Buy |
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Chemical Properties,Uses,Production
Uses
STX64 is a potent, irreversible inhibitor of steroid sulfatase.
Biochem/physiol Actions
STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.
storage
Store at -20°C
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 48)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| SembCorp Shenzhenshibai a Biotechnology Co., Ltd | 13412890622 | China | 23 | 55 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
BN 83495
Irosustat
STX 64
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
DSLPMJSGSBLWRE-UHFFFAOYSA-N
STX64 - BN83495 | Irosustat | 667 Coumate
COUMATE. Irosustat.
ST-64667
STX 64667
STX64; STX-64; STX 64; BN83495; BN-83495; BN 83495; STX 64667; STX64667; ST-64667; COUMATE. IROSUSTAT.
STX64667
Irosustat(STX64)
(6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate
Sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester
BN 83495,Irosustat,Inhibitor,STX-64,STX 64,inhibit,BN-83495
288628-05-7