SUMATRIPTAN-D6 HEMISUCCINATE
- CAS No.
- 1397195-80-0
- Chemical Name:
- SUMATRIPTAN-D6 HEMISUCCINATE
- Synonyms
- SUMATRIPTAN-D6 HEMISUCCINATE;3-[2-[di(methyl-d3)amino]ethyl]-N-methyl-1H-indole-5-methanesulfonamide, butanedioic acid (2:1)
- CBNumber:
- CB4259998
- Molecular Formula:
- C18H27N3O6S
- Molecular Weight:
- 413.49
- MDL Number:
- MFCD08063531
- MOL File:
- 1397195-80-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| NFPA 704 |
|
SUMATRIPTAN-D6 HEMISUCCINATE price More Price(2)
SUMATRIPTAN-D6 HEMISUCCINATE Chemical Properties,Uses,Production
Biological Activity
Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache.
References
1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)
SUMATRIPTAN-D6 HEMISUCCINATE Preparation Products And Raw materials
Raw materials
Preparation Products
SUMATRIPTAN-D6 HEMISUCCINATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4272 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| Shanghai isotope chemical co.,ltd | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
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