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Thalidezine

CAS No.
18251-36-0
Chemical Name:
Thalidezine
Synonyms
Thalidezine;Thalidesine;Thalidezine USP/EP/BP;5-O-DeMethylhernandezine;16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-20-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-
CBNumber:
CB42614230
Molecular Formula:
C38H42N2O7
Molecular Weight:
638.75
MDL Number:
MOL File:
18251-36-0.mol

Thalidezine Properties

Melting point 158-159℃
Boiling point 735.0±60.0 °C(Predicted)
Density 1.206±0.06 g/cm3 (20 ºC 760 Torr)
pka 9.71±0.20(Predicted)

Thalidezine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T338600 Thalidezine 18251-36-0 1mg $165 2021-12-16 Buy
Product number Packaging Price Buy
T338600 1mg $165 Buy

Thalidezine Chemical Properties,Uses,Production

Description

A further alkaloid of the bisbenzylisoquinoline type found in Thalictrum fendleri Engelm, this base yields colourless crystals from Me2CO and has [α]25D + 236° (CHCl3). The ultraviolet spectrum has one absorption maximum at 283 mJ.1. The D-methyl ether is identical with Hernandezine (q.v.). The D-ethy1 ether forms colourless crystals with m.p. 117-120° C.

Uses

Thalidezine is an isoquinoline alkaloid used in the treatments of cancers and neurodegenerative diseases.

References

Shamma, Shine, Dudock., Tetrahedron, 23, 2887 (1967)

Thalidezine Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidezine 5-O-DeMethylhernandezine Thalidesine 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-20-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)- Thalidezine USP/EP/BP 18251-36-0