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LEE011

LEE011 Structure
LEE011 structure
CAS No.
1256963-02-6
Chemical Name:
LEE011
Synonyms
Rebosini;Ribociclib(LEE011);4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;CS-842;LEE011;CDK4-IN-1;CDK4 inhibitor;CDK4/6 inhibitor;LEE011 USP/EP/BP;Ribociclib Free Base
CBNumber:
CB42655411
Molecular Formula:
C22H29ClN8
Molecular Weight:
440.97
MDL Number:
MFCD25976762
MOL File:
1256963-02-6.mol
MSDS File:
SDS
Last updated:2023-08-02 13:13:13
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LEE011 Properties

Melting point >180°C (dec.)
Boiling point 679.3±65.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka 7.57±0.50(Predicted)
form Solid
color Beige
FDA UNII TK8ERE8P56

LEE011 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C228130 CDK4/6Inhibitor 1256963-02-6 25mg $1470 2021-12-16 Buy
Matrix Scientific 153615 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine 95% 1256963-02-6 1g $1656 2021-12-16 Buy
Biorbyt Ltd orb181278 Ribociclib (LEE011) >99% 1256963-02-6 1g $1802 2021-12-16 Buy
Biorbyt Ltd orb546255 Ribociclib >98% 1256963-02-6 10mg $190.4 2021-12-16 Buy
Biorbyt Ltd orb546255 Ribociclib >98% 1256963-02-6 50mg $430.1 2021-12-16 Buy
Product number Packaging Price Buy
C228130 25mg $1470 Buy
153615 1g $1656 Buy
orb181278 1g $1802 Buy
orb546255 10mg $190.4 Buy
orb546255 50mg $430.1 Buy

LEE011 Chemical Properties,Uses,Production

Description

LEE011 (also known as ribociclib) is a CDK4/6 inhibitor. It has been recently approved by FDA (brand name: Kisqali®) to be combined with an aromatase inhibitor for initial endocrine-based therapy for treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis. 

References

S. Kim et al. "Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer." Molecular Cancer Therapeutics 12.11_Supplement (2013):PR02-PR02.
Bardia, Aditya, et al. "Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer." Asco  2014.
https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment

Uses

CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer.

LEE011 Preparation Products And Raw materials

Raw materials

Preparation Products

LEE011 Suppliers

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951 CHINA 115 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21689 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9341 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Beijing Yibai Biotechnology Co., Ltd 		0086-182-6772-3597 sales04@yibaibiotech.com CHINA 419 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 15319487004 1015@dideu.com China 2263 58
Echemi Group 		86-18905328650 18905328650 pharma@echemi.com CHINA 215 58
Supplier Advantage
shandong perfect biotechnology co.ltd 		58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Beijing Yibai Biotechnology Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Echemi Group 		58

View Lastest Price from LEE011 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ribociclib pictures 2024-03-12 Ribociclib
1256963-02-6
 US $0.00 / g 1g 98% HPLC 1kg shandong perfect biotechnology co.ltd
LEE011/ Ribociclib pictures 2023-07-31 LEE011/ Ribociclib
1256963-02-6
 US $10.00-20.00 / kg 1kg 99% 20tons Hebei Linwo New Material Technology Co., LTD
LEE011 pictures 2021-10-20 LEE011
1256963-02-6
 US $95.00-84.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biotechnology Co., Ltd.
  • Ribociclib pictures
  • Ribociclib
    1256963-02-6
  • US $0.00 / g
  • 98% HPLC
  • shandong perfect biotechnology co.ltd
  • LEE011/ Ribociclib pictures
  • LEE011/ Ribociclib
    1256963-02-6
  • US $10.00-20.00 / kg
  • 99%
  • Hebei Linwo New Material Technology Co., LTD
  • LEE011 pictures
  • LEE011
    1256963-02-6
  • US $95.00-84.00 / KG
  • 99%
  • Hebei Lingding Biotechnology Co., Ltd.

1256963-02-6(LEE011)Related Search:

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4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 1110813-31-4 918504-65-1

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LEE011 CDK4/6 inhibitor CDK4 inhibitor CDK4-IN-1 CDK 4/6 Inhibitor, >=98% Ribociclib(Lee011 & CDK 4/6 inhibitor) 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine 4-(3-chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine Ribociclib Free Base 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)py CS-842 2-Pyrimidinamine, 4-[3-chloro-5-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]- LEE011 USP/EP/BP 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine Ribociclib(LEE011) Rebosini 1256963-02-6 C22H29ClN8 Inhibitors