RKI1447
- CAS No.
- 1342278-01-6
- Chemical Name:
- RKI1447
- Synonyms
- RKI-1447;RKI 1447;CS-855;RKI1447;RKI-1447, >=98%;RKI 1447; RKI1447;RKI1447 USP/EP/BP;7-Pentahydroxyflavone;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
- CBNumber:
- CB42660015
- Molecular Formula:
- C16H14N4O2S
- Molecular Weight:
- 326.37
- MDL Number:
- MFCD26142658
- MOL File:
- 1342278-01-6.mol
- MSDS File:
- SDS
| Melting point | >205oC (dec.) |
|---|---|
| Density | 1.408±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 6.36±0.70(Predicted) |
| form | Solid |
| color | Pale Yellow to Pale Beige |
| FDA UNII | F8GZ6C9MKZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P305+P351+P338 |
RKI1447 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16278 | RKI-1447 ≥98% | 1342278-01-6 | 5mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 16278 | RKI-1447 ≥98% | 1342278-01-6 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16278 | RKI-1447 ≥98% | 1342278-01-6 | 50mg | $422 | 2024-03-01 | Buy |
| TRC | R550000 | RKI-1447 | 1342278-01-6 | 100mg | $875 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181117 | RKI-1447 >98% | 1342278-01-6 | 250mg | $1356.6 | 2021-12-16 | Buy |
RKI1447 Chemical Properties,Uses,Production
Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).
Uses
RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.
References
[1] patel r a et al. , rki-1447 is a potent inhibitor of the rho-associated rock kinases with anti-invasive and antitumor activities in breast cancer. cancer res, 2012, 72(19): 5025-5034.
RKI1447 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28200 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
