GLPG 0492
- CAS No.
- 1215085-92-9
- Chemical Name:
- GLPG 0492
- Synonyms
- GLPG 0492;GLPG-0492 (GLPG0492);4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile;Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-
- CBNumber:
- CB42667074
- Molecular Formula:
- C19H14F3N3O3
- Molecular Weight:
- 389.33
- MDL Number:
- MOL File:
- 1215085-92-9.mol
| Melting point | 66 - 71°C |
|---|---|
| Boiling point | 544.0±60.0 °C(Predicted) |
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) |
| pka | 13.50±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | 8O59X1ACZT |
GLPG 0492 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29938 | GLPG0492 | 1215085-92-9 | 1mg | $384 | 2024-03-01 | Buy |
| TRC | G411000 | GLPG-0492 | 1215085-92-9 | 2.5mg | $425 | 2021-12-16 | Buy |
| TRC | G411000 | GLPG-0492 | 1215085-92-9 | 25mg | $2360 | 2021-12-16 | Buy |
| AK Scientific | 3883DP | 4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile | 1215085-92-9 | 1mg | $525 | 2021-12-16 | Buy |
| Crysdot | CD31004258 | GLPG0492 98+% | 1215085-92-9 | 50mg | $1042 | 2021-12-16 | Buy |
GLPG 0492 Chemical Properties,Uses,Production
Description
GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.
Uses
GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues.
GLPG 0492 Preparation Products And Raw materials
Raw materials
Preparation Products
GLPG 0492 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 882 | 58 |
| Hebei Shengyuan Jinlong Import and Export Co. LTD | +8617367750398 | info@hebeisyjl.com | China | 1867 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
View Lastest Price from GLPG 0492 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-08 | GLPG0492
1215085-92-9
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd | |
 |
2023-11-27 | GLPG-0492
1215085-92-9
|
US $0.00 / gram | 10gram | 99% min | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd | |
 |
2023-09-05 | GLPG0492
1215085-92-9
|
US $0.00-0.00 / kg | 1kg | 99.9% | 20tons | Hebei Xinsheng New Material Technology Co., LTD. |