ChemicalBook >> CAS DataBase List >>PFK-158
PFK-158
- CAS No.
- 1462249-75-7
- Chemical Name:
- PFK-158
- Synonyms
- PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
- CBNumber:
- CB43034954
- Molecular Formula:
- C18H11F3N2O
- Molecular Weight:
- 328.29
- MDL Number:
- MOL File:
- 1462249-75-7.mol
Last updated:2023-05-21 10:59:17
| Boiling point | 466.3±45.0 °C(Predicted) |
|---|---|
| Density | 1.346±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM) |
| form | A crystalline solid |
| pka | 2.46±0.10(Predicted) |
| FDA UNII | 2HOK1JQ203 |
PFK-158 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3145 | PFK-158 ≥98% (HPLC) | 1462249-75-7 | 5MG | $86.8 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML3145 | PFK-158 ≥98% (HPLC) | 1462249-75-7 | 25MG | $280 | 2023-06-20 | Buy |
| Cayman Chemical | 22987 | PFK158 ≥95% | 1462249-75-7 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 22987 | PFK158 ≥95% | 1462249-75-7 | 10mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 22987 | PFK158 ≥95% | 1462249-75-7 | 25mg | $220 | 2024-03-01 | Buy |
PFK-158 Chemical Properties,Uses,Production
Description
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.
PFK-158 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 65)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
PFK-158
PFK-158, ACT-PFK-158
(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one
PFK-158;PFK 158
PFK-158 free base
2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-
(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one
p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one
1462249-75-7
1462249-75-1
C18H11F3N2O