A-196
- CAS No.
- 1982372-88-2
- Chemical Name:
- A-196
- Synonyms
- A-196;SGC A-196;A-196 (A196;A-196;A 196;A196;A196,Histone Methyltransferase,A-196,Inhibitor,inhibit;6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine;6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine;1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-
- CBNumber:
- CB43051065
- Molecular Formula:
- C18H16Cl2N4
- Molecular Weight:
- 359.25
- MDL Number:
- MOL File:
- 1982372-88-2.mol
| Boiling point | 584.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.399±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 5 mg/ml) |
| pka | 3.96±0.30(Predicted) |
| form | powder |
| color | white to light brown |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Symbol(GHS) | GHS06 |
| Signal word | Danger |
| Signal word | Danger |
| Hazard statements | H301 |
| Hazard statements | H301 |
| Precautionary statements | P301+P330+P331+P310 |
| Precautionary statements | P301+P330+P331+P310 |
| RIDADR | UN 2811 6.1 / PGIII |
A-196 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1565 | A-196 ≥98% (HPLC) | 1982372-88-2 | 5MG | $117 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1565 | A-196 ≥98% (HPLC) | 1982372-88-2 | 25MG | $382 | 2023-06-20 | Buy |
| Cayman Chemical | 18317 | A-196 ≥98% | 1982372-88-2 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18317 | A-196 ≥98% | 1982372-88-2 | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 18317 | A-196 ≥98% | 1982372-88-2 | 5mg | $109 | 2024-03-01 | Buy |
A-196 Chemical Properties,Uses,Production
Description
A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC50s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC50 values less than 1 μM. For more information on A-196 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2043 (A-197), for A-196 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
Uses
A-196 is a potent inhibitor of SUV420H1.
Biochem/physiol Actions
A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. For full characterization details, please visit the A-196 probe summary on the Structural Genomics Consortium (SGC) website.SGC2043 is the negative control for the active probe, A-196. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at +4°C
References
1) Bromberg?et al.?(2017),?The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol.?13?317
A-196 Preparation Products And Raw materials
Raw materials
Preparation Products
A-196 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |