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Dolutegravir Impurity 6
- CAS No.
- 1357289-29-2
- Chemical Name:
- Dolutegravir Impurity 6
- Synonyms
- Dotiravir Impurity 12;Dolutegravir RR Isomer;Dolutegravir Impurity 6;Doultegravirr RR Isomer;Dolutegravir Impurity 42;Dolutegravir R,R Freebase / R,R-ISomer;4-(3-chlorothiophen-2-yl)-1,3-thiazol-2-amine;(4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-(2,5-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4, 6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine9-carboxamide;(4R,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12, 12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H- pPyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
- CBNumber:
- CB43154308
- Molecular Formula:
- C20H19F2N3O5
- Molecular Weight:
- 419.38
- MDL Number:
- MOL File:
- 1357289-29-2.mol
Last updated:2023-07-12 17:01:43
| Boiling point | 669.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| pka | 4.50±1.00(Predicted) |
| FDA UNII | KA8ZEA9QPD |
Dolutegravir Impurity 6 Chemical Properties,Uses,Production
Uses
Dolutegravir RR Isomer is an isomer of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Dolutegravir Impurity 6 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 44)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Guangzhou PI PI Biotech Inc | +86-020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3635 | 55 |
| Aurisco Pharmaceutical (Tianjin) Inc. | 022-59885855 | liuyujie@aurisco.com | China | 96 | 58 |
| Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd. | 020-89854820 | sales@jzpharma.cn | China | 1050 | 58 |
| Beijing Comparison Pharmaceutical Technology Co., Ltd | 010-52878169 15701683040 | sales@bjcomparison.com | China | 4713 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 7937 | 55 |
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1of4
Dolutegravir Impurity 6
Dolutegravir RR Isomer
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aR)-
(4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Dolutegravir Impurity 42
Doultegravirr RR Isomer
Dolutegravir R,R Freebase / R,R-ISomer
4-(3-chlorothiophen-2-yl)-1,3-thiazol-2-amine
(4R,12aS)-N-(2,5-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4, 6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine9-carboxamide
(4R,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12, 12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H- pPyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Dotiravir Impurity 12
1357289-29-2