FIN56
- CAS No.
- 1083162-61-1
- Chemical Name:
- FIN56
- Synonyms
- FIN56;FIN-56;FIN 56;FIN56 >=98% (HPLC);FIN56;FIN-56 ;FIN 56;N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;9H-Fluorene-2,7-disulfonamide, N2,N7-dicyclohexyl-9-(hydroxyimino)-;FIN56 N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;inhibit,GPX4,FIN56,Ferroptosis,degradation,FIN 56,Inhibitor,squalene,synthase,FIN-56
- CBNumber:
- CB43160424
- Molecular Formula:
- C25H31N3O5S2
- Molecular Weight:
- 517.66
- MDL Number:
- MFCD30480929
- MOL File:
- 1083162-61-1.mol
| Boiling point | 759.1±70.0 °C(Predicted) |
|---|---|
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO (>25 mg/ml) |
| pka | 10.10±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
FIN56 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1740 | FIN56 ≥98% (HPLC) | 1083162-61-1 | 5MG | $107 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1740 | FIN56 ≥98% (HPLC) | 1083162-61-1 | 25MG | $434 | 2023-06-20 | Buy |
| Cayman Chemical | 25180 | FIN56 ≥98% | 1083162-61-1 | 5mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 25180 | FIN56 ≥98% | 1083162-61-1 | 10mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 25180 | FIN56 ≥98% | 1083162-61-1 | 25mg | $249 | 2024-03-01 | Buy |
FIN56 Chemical Properties,Uses,Production
Description
FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2
Definition
ChEBI: FIN56 is a fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. It has a role as a ferroptosis inducer and an EC 1.11.1.9 (glutathione peroxidase) inhibitor. It is a member of fluorenes, a ketoxime and a sulfonamide. It is functionally related to a 9-hydroxyiminofluorene-2,7-disulfonamide.
Biochem/physiol Actions
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.
storage
Store at +4°C
References
Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497 Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610
FIN56 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12740 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
