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IWP-051

IWP-051 structure

CAS No.: 1354041-91-0

Chemical Name:: IWP-051

Synonyms: IWP-051;4(3H)-Pyrimidinone, 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-

CBNumber:: CB43304417

Molecular Formula:: C17H11F2N5O2

Molecular Weight:: 355.3

MDL Number:

MOL File:: 1354041-91-0.mol

Last updated:2023-03-31 09:12:59

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IWP-051 Properties

Density	1.53±0.1 g/cm3(Predicted)
pka	5.03±0.50(Predicted)

IWP-051 Chemical Properties,Uses,Production

Description

IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.

IWP-051 Preparation Products And Raw materials

Raw materials

Preparation Products

IWP-051 Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

IWP-051 4(3H)-Pyrimidinone, 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]- 1354041-91-0