PF-543
- CAS No.
- 1706522-79-3
- Chemical Name:
- PF-543
- Synonyms
- PF 543 HCl;WNKWAZFYPZMDGJ-VQIWEWKSSA-N;PF-543 Hydrochloride DISCONTINUED;(2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride;Nrf-2,PF543 hydrochloride,anti-cancer,sphingosine-competitive,S1P,Sphingosine Kinase 1 Inhibitor II,Apoptosis,inhibit,PF 543,Lysophospholipid Receptor,PAH,necrosis,SphK,Inhibitor,Autophagy,PF543,PF 543 hydrochloride,caspase-3/7,SK1,Sphingosine kinase,LPL Receptor,anti-inflammatory
- CBNumber:
- CB43355459
- Molecular Formula:
- C27H32ClNO4S
- Molecular Weight:
- 502.07
- MDL Number:
- MOL File:
- 1706522-79-3.mol
PF-543 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17034 | PF-543 (hydrochloride) ≥98% | 1706522-79-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17034 | PF-543 (hydrochloride) ≥98% | 1706522-79-3 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 17034 | PF-543 (hydrochloride) ≥98% | 1706522-79-3 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 17034 | PF-543 (hydrochloride) ≥98% | 1706522-79-3 | 25mg | $381 | 2024-03-01 | Buy |
| Ambeed | A451925 | PF543HCl 97% | 1706522-79-3 | 100mg | $481 | 2021-12-16 | Buy |
PF-543 Chemical Properties,Uses,Production
Uses
(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol, is a novel Sphingonise Kinas 1 (SphK1, SK1) inhibitor.
Enzyme inhibitor
This potent SphK1 inhibitor (FWHCl-Salt = 502.07 g/mol; CAS 1706522-79- 3; Solubility: 10 mM in H2O, with gentle warming; 100 mM in DMSO), also named (2R)-1-[[(4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy] methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride, selectively targets sphingosine kinase 1 (IC50 = 2 nM; Ki = 3.6 nM). The latter phosphorylates sphingosine to form sphingosine-1-phosphate (S1P), a lipid messenger with both intracellular functions (regulating cell proliferation and survival) and extracellular functions (as a ligand for EDG1, or sphingosine-1-phosphate receptor 1). PF-543 also exhibits >100-fold selectivity for Sphk1 over Sphk2 as well as >5000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. P 543 attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro. It also suppresses human colorectal cancer cell line HCT-116 as a tumor xenograft growth in mice
storage
Desiccate at RT
PF-543 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-543 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| YouCoChem (Beijing) Chemical Technology Co., Ltd. | 18800159827 | youcochem@163.com | China | 161 | 50 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2993 | 58 |