[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
![[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Structure](CAS/20180601/GIF/951612-19-4.gif)
- CAS No.
- 951612-19-4
- Chemical Name:
- [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
- Synonyms
- L524-0366;L524 0366,L5240366,L-524-0366;[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone;(1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone;Methanone, [1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-4-thiomorpholinyl-
- CBNumber:
- CB43916832
- Molecular Formula:
- C13H13ClN4OS
- Molecular Weight:
- 308.79
- MDL Number:
- MOL File:
- 951612-19-4.mol
| storage temp. | -20°C (des.) |
|---|---|
| solubility | Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming). |
| form | solid |
| color | Beige |
| Stability | Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Chemical Properties,Uses,Production
Description
L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD?= 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.1?L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.2
References
1) Dhruv?et al. (2013),?Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis; J. Biol. Chem.,?288?32261 2) Cheng?et al. (2013),?TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic; Front. Immunol.,?4?473
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Preparation Products And Raw materials
Raw materials
Preparation Products
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |