Linocaine hydrochloride
- CAS No.
- 6108-05-0
- Chemical Name:
- Linocaine hydrochloride
- Synonyms
- LINOCAINE HCL;Linocaine hydrochlor;Linocaine hydrochloride(lidocaine HCL);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate;ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE;dolicaine;Lidocaine HC1;Lidocaine HCl USP;N-Oxide Lidocaine-d;LIDOCAINE HCL HYDRATE
- CBNumber:
- CB4486868
- Molecular Formula:
- C14H25ClN2O2
- Molecular Weight:
- 288.82
- MDL Number:
- MFCD00150329
- MOL File:
- 6108-05-0.mol
- MSDS File:
- SDS
| Melting point | 75-79℃ |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | solid |
| color | white |
| Water Solubility | Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether. |
| InChI | InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2 |
| InChIKey | YECIFGHRMFEPJK-UHFFFAOYSA-N |
| SMILES | C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl |
| LogP | 2.359 (est) |
| CAS DataBase Reference | 6108-05-0(CAS DataBase Reference) |
| FDA UNII | V13007Z41A |
Linocaine hydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L5647 | Lidocaine hydrochloride monohydrate solid | 6108-05-0 | 15g | $98.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1366013 | Lidocaine hydrochloride United States Pharmacopeia (USP) Reference Standard | 6108-05-0 | 150mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP214 | Lidocaine hydrochloride British Pharmacopoeia (BP) Reference Standard | 6108-05-0 | 100MG | $252 | 2023-06-20 | Buy |
| Alfa Aesar | J63035 | Lidocaine hydrochloride monohydrate, 98% | 6108-05-0 | 5g | $32.65 | 2024-03-01 | Buy |
| Alfa Aesar | J63035 | Lidocaine hydrochloride monohydrate, 98% | 6108-05-0 | 25g | $104 | 2024-03-01 | Buy |
Linocaine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.
Uses
Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Application
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
Definition
ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
brand name
Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).
Contact allergens
Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.
Mode of action
Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.
Linocaine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 154 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6709 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 881 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 956 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 270 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 371 | 58 |
| Nanjing Deda New Material Technology Co., Ltd | +8613223293093 | bella@njdeda.com | China | 82 | 58 |
| Apeloa production Co.,Limited | +86-19131931000 +86-19131931000 | admin@apcl.com.cn | China | 196 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-199-55145978 +8619955145978 | sales8@anhuiyiao.com | China | 253 | 58 |
Related articles
- Usage and Application of Linocaine hydrochloride
- Lidocaine hydrochloride is a medium effect amides local anesthetic used as a local anesthetic and antiarrhythmic drug
- Aug 11，2022
View Lastest Price from Linocaine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-13 | Linocaine hydrochloride
6108-05-0
|
US $5.00-1.00 / kg | 1kg | 99.5 | 10 ton per month | Nanjing Deda New Material Technology Co., Ltd | |
 |
2024-05-08 | Linocaine hydrochloride
6108-05-0
|
US $0.00-0.00 / KG | 1KG | USP, BP | 5,000KG | Hangzhou Hyper Chemicals Limited | |
 |
2024-05-08 | Lidocaine HCL
6108-05-0
|
US $1.00 / g | 1g | 98% | 1000 | Apeloa production Co.,Limited |
-
- Linocaine hydrochloride
6108-05-0
- US $5.00-1.00 / kg
- 99.5
- Nanjing Deda New Material Technology Co., Ltd
-
- Linocaine hydrochloride
6108-05-0
- US $0.00-0.00 / KG
- USP, BP
- Hangzhou Hyper Chemicals Limited
-
- Lidocaine HCL
6108-05-0
- US $1.00 / g
- 98%
- Apeloa production Co.,Limited