ChemicalBook >> CAS DataBase List >>ZEBULARINE
ZEBULARINE
- CAS No.
- 3690-10-6
- Chemical Name:
- ZEBULARINE
- Synonyms
- NSC 309132;4-Deoyuridine;4-Deoxyuridine;Zebularine Zebularine;Zebularine (NSC309132;NSC309132;4-DEOXYURIDINE;4-Deoyuridine,Zebularine;2-Pyrimidone-1-β-D-riboside;Uridine Impurity 23 (Zebularine);Pyrimidin-2-one -D-Ribofuranoside
- CBNumber:
- CB4497499
- Molecular Formula:
- C9H12N2O5
- Molecular Weight:
- 228.2
- MDL Number:
- MFCD04973699
- MOL File:
- 3690-10-6.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 160-162?C |
|---|---|
| Boiling point | 499.0±55.0 °C(Predicted) |
| Density | 1.73±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 16 mg/mL, soluble |
| form | solid |
| pka | 13.48±0.70(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| InChIKey | RPQZTTQVRYEKCR-WCTZXXKLSA-N |
| FDA UNII | 7A9Y5SX0GY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P264-P270-P301+P312-P330 |
| WGK Germany | 3 |
| RTECS | UW7539720 |
| HS Code | 2934999090 |
ZEBULARINE price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 691400 | Zebularine | 3690-10-6 | 10mg | $216 | 2024-03-01 | Buy |
| Sigma-Aldrich | 691400 | Zebularine | 3690-10-6 | 25mg | $475 | 2024-03-01 | Buy |
| TCI Chemical | Z0022 | Zebularine >98.0%(HPLC)(T) | 3690-10-6 | 200mg | $193 | 2024-03-01 | Buy |
| TCI Chemical | Z0022 | Zebularine >98.0%(HPLC)(T) | 3690-10-6 | 1g | $571 | 2024-03-01 | Buy |
| Cayman Chemical | 10975 | Zebularine ≥98% | 3690-10-6 | 1mg | $26 | 2024-03-01 | Buy |
ZEBULARINE Chemical Properties,Uses,Production
Description
Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.
Chemical Properties
White Solid
Uses
It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.
Definition
ChEBI: Zebularine is a member of pyrimidine ribonucleosides.
Biological Activity
Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Also inhibits cytidine deaminase (K i ~ 2 μ M).
Biochem/physiol Actions
Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.
storage
Desiccate at RT
ZEBULARINE Preparation Products And Raw materials
Raw materials
Preparation Products
ZEBULARINE Suppliers
Global( 109)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1642 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD | 0371-55159968 18137130222 | haifeng.zhang@pannacean.com | China | 409 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
3690-10-6(ZEBULARINE)Related Search:
5-METHYLCYTIDINE
6-[(3-chloropropyl)amino]-1,3-dimethyluracil
URAPIDIL 5-METHYL-
Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine
Pseudouridine
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
2-Demethoxy-4-methoxy urapidil
Quillaic acid
(8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-ene-3,16-dione
Alisol B acetate
1of4
4-Deoyuridine
1-b-D-ribofuranosyl-2-(1H)-pyriMidinone
anticancer drug, DNA Methylation inhibitor
2(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
2-Pyrimidone-1-β-D-riboside
1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone
Pyrimidin-2-one beta-D-ribofuranoside
1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one
pyrimidin-2-one beta-ribofuranoside
1--D-Ribofuranosyl-2(1H)-pyrimidinone
4-Deoxyuridine
NSC 309132
Pyrimidin-2-one -D-Ribofuranoside
1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
2(1H)-PyriMidinone, 1-b-D-ribofuranosyl-
Zebularine Zebularine
Uridine Impurity 23 (Zebularine)
4-Deoyuridine, 1-beta-D-ribofuranosyl-2-(1H)-pyrimidinone
Zebularine (NSC309132
2-HYDROXY-PYRIMIDINE-1-B-D-RIBOSIDE
Zebularine - CAS 3690-10-6 - Calbiochem
NSC309132;4-DEOXYURIDINE
1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
1-beta-D-Ribofuranosyl -l ,2-dihydropyrimidin-2-one
NSC 309132,NSC-309132,DNMTs,Inhibitor,DNA MTases,Autophagy,Zebularine,DNA Methyltransferase,inhibit
4-Deoyuridine,Zebularine
3690-10-6
Carbohydrates & Derivatives
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals