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JKE-1674

JKE-1674 structure

CAS No.: 2421119-60-8

Chemical Name:: JKE-1674

Synonyms: JKE-1674;1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime;(E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one;ML210,glutathione,Ferroptosis,JKE-1674,peroxidase,inhibit,JKE 1674,Glutathione Peroxidase,rescued,Inhibitor,JKE1674

CBNumber:: CB46197997

Molecular Formula:: C20H20Cl2N4O4

Molecular Weight:: 451.3

MDL Number:: MFCD34567701

MOL File:: 2421119-60-8.mol

Last updated:2023-05-21 10:59:17

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JKE-1674 Properties

Boiling point	595.5±60.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO: soluble
form	A crystalline solid
pka	6.67±0.58(Predicted)

JKE-1674 Chemical Properties,Uses,Production

Biological Activity

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1 JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 μM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .

References

1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)

JKE-1674 Preparation Products And Raw materials

Raw materials

Preparation Products

JKE-1674 Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	1014988033@qq.com	China	4981	55
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Universal Biotech Co.,Ltd	18768175414	gaojun@univ-bio.com	China	24998	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Beijing Biocreative Technology Co., Ltd.	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
MQ (shanghai) Pharmaceuticals Co., Ltd.	55
DC Chemicals	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai Universal Biotech Co.,Ltd	58
TargetMol Chemicals Inc.	58

JKE-1674 ML210,glutathione,Ferroptosis,JKE-1674,peroxidase,inhibit,JKE 1674,Glutathione Peroxidase,rescued,Inhibitor,JKE1674 1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime (E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one 2421119-60-8