ChemicalBook >> CAS DataBase List >>BO-264
BO-264
- CAS No.
- 2408648-20-2
- Chemical Name:
- BO-264
- Synonyms
- BO-264;3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine;4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-;inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
- CBNumber:
- CB46199294
- Molecular Formula:
- C18H19N5O3
- Molecular Weight:
- 353.38
- MDL Number:
- MOL File:
- 2408648-20-2.mol
Last updated:2023-09-20 16:43:00
| Boiling point | 627.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.306±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| pka | 6.69±0.10(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BO-264 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0116466 | BO-264 99.63% | 2408648-20-2 | 10mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-0116466 | BO-264 99.63% | 2408648-20-2 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0116466 | BO-264 99.63% | 2408648-20-2 | 100mg | $720 | 2021-12-16 | Buy |
| ChemScene | CS-0116466 | BO-264 99.63% | 2408648-20-2 | 250mg | $1300 | 2021-12-16 | Buy |
BO-264 Chemical Properties,Uses,Production
Description
BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.
References
References:
BO-264 Preparation Products And Raw materials
Raw materials
Preparation Products
BO-264 Suppliers
Global( 52)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 991 | 55 |
2408648-20-2(BO-264)Related Search:
BO-264
4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-
3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine
inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
2408648-20-2