ChemicalBook >> CAS DataBase List >>SR-717
SR-717
- CAS No.
- 2375421-09-1
- Chemical Name:
- SR-717
- Synonyms
- SR171;SR-717;SR-717 lithium;SR171&SR-717 lithium;SR 717 (lithium salt);Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate;immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
- CBNumber:
- CB47247714
- Molecular Formula:
- C15H10F2LiN5O3
- Molecular Weight:
- 353.21
- MDL Number:
- MOL File:
- 2375421-09-1.mol
Last updated:2023-06-08 09:03:02
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| color | Off-white |
| Water Solubility | Water: < 0.1 mg/mL (insoluble) |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
SR-717 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0135108 | SR-717 99.75% | 2375421-09-1 | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0135108 | SR-717 99.75% | 2375421-09-1 | 10mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0135108 | SR-717 99.75% | 2375421-09-1 | 25mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0135108 | SR-717 99.75% | 2375421-09-1 | 50mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-0135108 | SR-717 99.75% | 2375421-09-1 | 100mg | $950 | 2021-12-16 | Buy |
SR-717 Chemical Properties,Uses,Production
Description
SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.
References
Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993
SR-717 Preparation Products And Raw materials
Raw materials
Preparation Products
SR-717 Suppliers
Global( 46)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4604 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509 | 643638326@qq.com | China | 5347 | 58 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232 | 1282296214@qq.com | China | 496 | 55 |
2375421-09-1(SR-717)Related Search:
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SR-717
SR171
SR-717 lithium
SR 717 (lithium salt)
immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
SR171&SR-717 lithium
2375421-09-1