Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Structure
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- structure
CAS No.
2272976-28-8
Chemical Name:
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-
Synonyms
JUN76288;WEE1-IN-3;WEE1IN3,cycle,Inhibitor,inhibit,cell,Wee1,WEE-1-IN-3,WEE1 IN 3,Anticancer;3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-
CBNumber:
CB48344500
Molecular Formula:
C28H31N7O2
Molecular Weight:
497.59
MDL Number:
MOL File:
2272976-28-8.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Properties

Boiling point 702.4±70.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (502.42 mM; Need ultrasonic)
pka 13.26±0.29(Predicted)

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 5mg $400 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 10mg $680 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 25mg $1350 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 50mg $2200 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 100mg $3400 2021-12-16 Buy
Product number Packaging Price Buy
CS-0146345 5mg $400 Buy
CS-0146345 10mg $680 Buy
CS-0146345 25mg $1350 Buy
CS-0146345 50mg $2200 Buy
CS-0146345 100mg $3400 Buy

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Chemical Properties,Uses,Production

Biological Activity

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities[1]. WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively[1].WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?Να repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1].

References

[1]. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9180 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
InvivoChem 		58
TargetMol Chemicals Inc. 		58
DC Chemicals 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
JUN76288 WEE1-IN-3 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- WEE1IN3,cycle,Inhibitor,inhibit,cell,Wee1,WEE-1-IN-3,WEE1 IN 3,Anticancer 2272976-28-8