Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CDK4/6-IN-6

CDK4/6-IN-6

CDK4/6-IN-6 Structure
CDK4/6-IN-6 structure
CAS No.
2380321-51-5
Chemical Name:
CDK4/6-IN-6
Synonyms
PF-07220060;CDK4/6-IN-6;CDK4-IN-I (PF-07220060);CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol
CBNumber:
CB48845087
Molecular Formula:
C22H27ClFN5O3
Molecular Weight:
463.94
MDL Number:
MOL File:
2380321-51-5.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

CDK4/6-IN-6 Properties

Boiling point 687.4±65.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
pka 13.43±0.29(Predicted)

CDK4/6-IN-6 Chemical Properties,Uses,Production

Biological Activity

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

References

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

CDK4/6-IN-6 Preparation Products And Raw materials

Raw materials

Preparation Products

CDK4/6-IN-6 Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4604 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4164 58
Shanghai Sphchem Co., Ltd. 21-21-56491756 13512199871 sales@panhongchem.com China 4000 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3423 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4153 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 18122150900 sculk28@163.com China 646 55
Shanghai PharmaPartner Co., Ltd. 13621689085 pharmabridge@163.com China 501 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Sphchem Co., Ltd. 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 55
Shanghai PharmaPartner Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
CDK4/6-IN-6 1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol PF-07220060 CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6 CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6 (3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol CDK4-IN-I (PF-07220060) 2380321-51-5