11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate)
- CAS No.
- 3863-59-0
- Chemical Name:
- 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate)
- Synonyms
- Corphos;NSC 529660;Cortisol phosphate;Cortisol 21-phosphate;Hydrocortisone phosphate;Cortisol 21-monophosphate;Hydrocortisone 21-phosphate;Cortisol 21-phosphoric acid;21-Hydrocortisonephosphoric acid;Hydrocortisone dihydrogen phosphate
- CBNumber:
- CB4900397
- Molecular Formula:
- C21H31O8P
- Molecular Weight:
- 442.44
- MDL Number:
- MOL File:
- 3863-59-0.mol
| Boiling point | 669.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 1.67±0.10(Predicted) |
| FDA UNII | 2Y87E22X71 |
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate) Chemical Properties,Uses,Production
Description
Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID). Hydrocortisone phosphate inhibits the biological activities of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone phosphate can be used in the study of ulcerative colitis (UC).
Originator
Corphos,Tilden Yates,US,1959
Uses
Glucocorticoid.
Definition
ChEBI: A steroid phosphate that is the 21-O-phospho derivative of cortisol.
Manufacturing Process
21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile
(125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and
triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4
hours. The solvent was removed in vacuo and the residue, dissolved in
ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb
225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with
20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate
was at first cloudy, but by the end of the elution it was clear and nonacid.
The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of
solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes.
The solid insoluble inorganic phosphate was filtered off and washed with
methanol (200 ml). The slightly cloudy filtrate was filtered again, and
evaporated to dryness in vacuo. The residual gum dissolved readily in water
(40 ml) and on addition of acetone (600 ml) to the solution a mixture of
sodium salts of hydrocortisone 21-phosphate separated as a white solid. This
was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2
hr to constant weight. Yield 4.45 g.
brand name
Hydrocortone (Merck).
Therapeutic Function
Glucocorticoid
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate) Preparation Products And Raw materials
Raw materials
Preparation Products
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| Supplier | Advantage |
|---|---|
| MedChemexpress LLC | 58 |
| Musechem | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| Absin Bioscience Inc. | 58 |