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1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride

CAS No.
16899-81-3
Chemical Name:
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride
Synonyms
U 12844A;Isoprenaline impurity A;Norepinephrine Impurity 10;Isoprenaline EP Impurity A;Isoprenaline impurity A CRS;Isoprenaline EP Impurity A HCl;Isoprenaline HCl EP Impurity A;Isoprenaline HCl EP Impurity A HCl;Isoprenaline hydrochloride EP Impurity A;3',4'-DIHYDROXY-2-(ISOPROPYLAMINO)-ACETOPHENONE HYDROCHLORIDE
CBNumber:
CB4912824
Molecular Formula:
C11H15NO3.ClH
Molecular Weight:
245.704
MDL Number:
MFCD00035076
MOL File:
16899-81-3.mol
Last updated:2023-04-23 13:52:06

1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Properties

Melting point 255-257℃
FDA UNII X4JS3SRV5Y

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330

1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001577 Isoprenaline impurity A European Pharmacopoeia (EP) Reference Standard 16899-81-3 y0001577 $220 2024-03-01 Buy
Sigma-Aldrich S346322 Isoprenaline impurity A Aldrich 16899-81-3 50mg $179 2024-03-01 Buy
Product number Packaging Price Buy
Y0001577 y0001577 $220 Buy
S346322 50mg $179 Buy

1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Chemical Properties,Uses,Production

Uses

1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]-ethanone is an impurity of Isoprenaline (I874200, HCl salt) which is non-selective beta-adrenergic agonist. Isoprenaline is used in the treatment of bradycardia.

Preparation

Obtained by condensation of a-chloro-3,4- dihydroxy-acetophenone with isopropylamine in isopropanol at 65–70°. The amino ketone which separated was treated with concentrated hydrochloric acid (54%), (46%).

99-40-1
16899-81-3
Synthesis of 1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride from 2-Chloro-3',4'-dihydroxyacetophenone

1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Preparation Products And Raw materials

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1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride Ethanone,1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]-, hydrochloride (1:1) 1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]ethanone hydrochloride Isoprenaline impurity A U 12844A [2-(3,4-DIHYDROXYPHENYL)-2-OXOETHYL]-PROPAN-2-YLAZANIUM,CHLORIDE 3',4'-DIHYDROXY-2-(ISOPROPYLAMINO)-ACETOPHENONE HYDROCHLORIDE Norepinephrine Impurity 10 Isoprenaline EP Impurity A HCl Isoprenaline EP Impurity A Isoprenaline impurity A CRS Isoprenaline HCl EP Impurity A HCl Isoprenaline hydrochloride EP Impurity A Isoprenaline Hydrochloride Impurity 1(Isoprenaline Hydrochloride EP Impurity A) Isoprenaline HCl EP Impurity A 1-(3,4-dihydroxyphenyl)-2-(isopropyl amino) ethan-1-one Hydrochloride 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanone hydrochloride (Isoprenaline HCl Impurity) 16899-81-3