GUVACINE HYDROCHLORIDE
- CAS No.
- 6027-91-4
- Chemical Name:
- GUVACINE HYDROCHLORIDE
- Synonyms
- 1,2,5,6-Tetrahydro-;GUVACINE HYDROCHLORIDE;Norareca alkaloid hydrochloride;GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK;Guvacine hydrochloride >=97% (NMR), solid;1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
- CBNumber:
- CB4972615
- Molecular Formula:
- C6H10ClNO2
- Molecular Weight:
- 163.6021
- MDL Number:
- MFCD00055191
- MOL File:
- 6027-91-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
GUVACINE HYDROCHLORIDE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23361 | Guvacine (hydrochloride) ≥95% | 6027-91-4 | 25mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 23361 | Guvacine (hydrochloride) ≥95% | 6027-91-4 | 50mg | $101 | 2024-03-01 | Buy |
| Cayman Chemical | 23361 | Guvacine (hydrochloride) ≥95% | 6027-91-4 | 100mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 23361 | Guvacine (hydrochloride) ≥95% | 6027-91-4 | 250mg | $437 | 2024-03-01 | Buy |
| TRC | G876400 | Guvacine hydrochloride | 6027-91-4 | 100mg | $200 | 2021-12-16 | Buy |
GUVACINE HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Beige Solid
Uses
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Uses
Guvacine Hydrochloride is a GABA uptake inhibitor and it is used for the treatment of neurodegenerative diseases.
Biological Activity
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
in vitro
Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
GUVACINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from GUVACINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | GUVACINE HYDROCHLORIDE
6027-91-4
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
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- GUVACINE HYDROCHLORIDE
6027-91-4
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd