ChemicalBook >> CAS DataBase List >>2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-
- CAS No.
- 2241719-73-1
- Chemical Name:
- 2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-
- Synonyms
- ASP2453;Ras,inhibit,ASP2453,Inhibitor,ASP 2453,ASP-2453;2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-
- CBNumber:
- CB49950423
- Molecular Formula:
- C40H48F3N7O4
- Molecular Weight:
- 747.85
- MDL Number:
- MOL File:
- 2241719-73-1.mol
Last updated:2023-09-04 15:51:00
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Properties
Boiling point | 855.8±75.0 °C(Predicted) |
---|---|
Density | 1.36±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
pka | 12.36±0.40(Predicted) |
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Chemical Properties,Uses,Production
Biological Activity
ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
References
[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Suppliers
Global( 8)Suppliers
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Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
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Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3061 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
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Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Spectrum
2-Propen-1-one, 1-[7-[6-cyclopropyl-2-[[1-(3-methoxypropyl)-4-piperidinyl]oxy]-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-
ASP2453
Ras,inhibit,ASP2453,Inhibitor,ASP 2453,ASP-2453
2241719-73-1
C40H48F3N7O4