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Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- structure

CAS No.: 551909-15-0

Chemical Name:: Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-

Synonyms: RTICBM-189;Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-;Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior

CBNumber:: CB510051912

Molecular Formula:: C15H14Cl2N2O

Molecular Weight:: 309.19

MDL Number:

MOL File:: 551909-15-0.mol

Last updated:2023-09-04 16:42:00

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Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Properties

Boiling point	433.1±45.0 °C(Predicted)
Density	1.330±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 100 mg/mL (323.43 mM; Need ultrasonic)
pka	13.54±0.46(Predicted)

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties,Uses,Production

Biological Activity

RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1]. RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1].

References

[1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432.

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9767	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Shandong Jirun Biomedical Technology Co., Ltd.	0539-0539-8613587 17661611089	2639273505@qq.com	China	163	58
SINO High Goal Chemical Technology Co., Ltd.	021-57646680 18306277365	guoxin@chembiobanksh.com	China	2324	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
InvivoChem	58
TargetMol Chemicals Inc.	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
DC Chemicals	58
Shandong Jirun Biomedical Technology Co., Ltd.	58
SINO High Goal Chemical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Spectrum

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-(551909-15-0)¹HNMR

Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- RTICBM-189 Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior 551909-15-0