abciximab
- CAS No.
- 143653-53-6
- Chemical Name:
- abciximab
- Synonyms
- Reopro;CentoRx;Rheopro;c7E3 Fab;Abcixifiban;Unii-X85G7936gv;Research Grade Abciximab(DHC33301);Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain
- CBNumber:
- CB51319184
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | Store at -80°C |
|---|---|
| FDA UNII | X85G7936GV |
abciximab Chemical Properties,Uses,Production
Uses
Monoclonal antibody (antithrombotic).
brand name
ReoPro (Lilly).
Clinical Use
Antiplatelet agent:
Prevention of ischaemic cardiac complications
in patients undergoing percutaneous coronary
intervention
Short-term prevention of myocardial infarction
in patients with unstable angina not responding
to treatment or awaiting percutaneous coronary
intervention.
Enzyme inhibitor
This antithrombotic (MW = 47455 g/mol; CAS 143653-53-6; also known as Reopro?) consists of an immunoglobulin G1 Fab fragment from a chimeric human-murine monoclonal antibody directed against the human platelet glycoprotein IIb/IIIa receptor. Abciximab also facilitates the dispersal of newly formed platelet aggregates in vitro, by partially displacing fibrinogen from activated GPIIb/IIIareceptors. In vivo, abciximab may destabilize coronary thrombi by preventing aggregate formation and dispersing mural thrombi. Target(s): coagulation factor Xa, in presence of heparin; glycoprotein IIb/IIIa receptor.
Drug interactions
Potentially hazardous interactions with other drugs
Heparin, anticoagulants, antiplatelets and
thrombolytics: increased risk of bleeding.
Metabolism
Following IV administration, abciximab rapidly binds to the platelet GPIIb/IIIa receptors, and remains in the circulation for 15 days or more in a platelet-bound state. Metabolism is via proteolytic cleavage
abciximab Preparation Products And Raw materials
Raw materials
Preparation Products
abciximab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8015 | 62 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10054 | 58 |
| Wuhan Topule | +86-02787215551 +86-19945035818 | 2936752263@qq.com | China | 8284 | 58 |
143653-53-6(abciximab)Related Search:
1of4