ChemicalBook >> CAS DataBase List >>DMP 777

DMP 777

DMP 777 structure

CAS No.: 157341-41-8

Chemical Name:: DMP 777

Synonyms: DMP 777;L 694458;L-694458; DMP-777; DMP777;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)

CBNumber:: CB51333719

Molecular Formula:: C31H40N4O6

Molecular Weight:: 564.67

MDL Number:: MFCD00871548

MOL File:: 157341-41-8.mol

Last updated:2023-05-21 10:59:17

Request For Quotation

DMP 777 Properties

Density	1.227
storage temp.	Store at -20°C
solubility	DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	Powder
pka	pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)
FDA UNII	3Q0469283P

DMP 777 price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0355	DMP777 99.13%	157341-41-8	10mg	$300	2021-12-16	Buy
Biosynth Carbosynth	FB167347	(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide	157341-41-8	2mg	$300	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0001205	L-694458 95.00%	157341-41-8	5MG	$496.38	2021-12-16	Buy
ChemScene	CS-0355	DMP777 99.13%	157341-41-8	25mg	$510	2021-12-16	Buy
ChemScene	CS-0355	DMP777 99.13%	157341-41-8	5mg	$200	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0355	10mg	$300	Buy
FB167347	2mg	$300	Buy
KIN0001205	5MG	$496.38	Buy
CS-0355	25mg	$510	Buy
CS-0355	5mg	$200	Buy

DMP 777 Chemical Properties,Uses,Production

Biological Activity

DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).

in vivo

DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.

target

Human leukocyte elastase (HLE)

DMP 777 Preparation Products And Raw materials

Raw materials

Preparation Products

DMP 777 Suppliers

Global( 45)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6010	61
Shanghai Holy Biohemdeviser Co., Ltd	021-61551100		China	444	57
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Aladdin Scientific	58
Chembest Research Laboratories Limited	61
Shanghai Holy Biohemdeviser Co., Ltd	57
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
SPIRO PHARMA	55
BOC Sciences	65

157341-41-8(DMP 777)Related Search:

N,N'-Ethylenebis(stearamide) Sulfanilamide

DMP 777 (2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl) 1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)- (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe L 694458 (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution) L-694458; DMP-777; DMP777 157341-41-8 C31H40N4O6