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(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one

(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one Structure
(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one structure
CAS No.
2810-21-1
Chemical Name:
(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one
Synonyms
Stepharine;(+)-Stepharine;(+)-Stepharine;(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one;(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one;Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one, 2',3',8',8'a-tetrahydro-5',6'-dimethoxy-, (8'aR)-
CBNumber:
CB52323100
Molecular Formula:
C18H19NO3
Molecular Weight:
297.34836
MDL Number:
MFCD34550031
MOL File:
2810-21-1.mol
Last updated:2023-05-21 10:59:17
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(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one Properties

Melting point 179-181 °C
Boiling point 487.1±45.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
pka 8.08±0.20(Predicted)

(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one Chemical Properties,Uses,Production

Description

A spiroisoquinoline alkaloid from Stephania glabra, the base has [α]26D + 143° (c 1.88, CHCI3). It contains two methoxyl groups and an imino group and yields a crystalline N-acetyl derivative, m.p. 234-5°C; [α]24D- 80° (c 1.57, CHCI3). The N-methyl compound has been shown to be identical with Pronuciferine (q.v.).

References

Cava et al., Chern. Ind., 282 (1964)
Tomita et al., Tetrahedron Lett., 2825 (1965)
Baldwin et al., J. Chern. Soc., C, 154 (1967)
Circular dichroism: Snatzke, Wollenberg., J. Chern. Soc., C, 1681 (1966)

(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Greenpure Biopharma CO.,Ltd 		18283602253 jancyzheng@gcgreenpure.com China 952 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29796 68
Chengdu Greenpure Biopharma CO.,Ltd 028-88203606; 18283602253 jancyzheng@gcgreenpure.com China 1587 58
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 1388 58
Shanghai Bohu Biotechnology Co., LTD 021-57763112 13585886131 3004987436@qq.com China 9694 58
Aleshan (Guangzhou) Biotechnology Co., Ltd 18636736628 Araratbio@163.com China 3342 58
Shanghai Moqi Biological Technology Co., LTD 021-38218169 13341702378 190129269@qq.com China 9112 58
Wuhan Huangzhen Biochemical Co., Ltd 13795480948 13795480948 3450865996@qq.com China 4958 58
Supplier Advantage
Chengdu Greenpure Biopharma CO.,Ltd 		58
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Chengdu Greenpure Biopharma CO.,Ltd 58
BioBioPha Co., Ltd. 58
Shanghai Bohu Biotechnology Co., LTD 58
Aleshan (Guangzhou) Biotechnology Co., Ltd 58
Shanghai Moqi Biological Technology Co., LTD 58
Wuhan Huangzhen Biochemical Co., Ltd 58
(+)-Stepharine (8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one (8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one Stepharine Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one, 2',3',8',8'a-tetrahydro-5',6'-dimethoxy-, (8'aR)- (+)-Stepharine 2810-21-1