Thiamet G Discontinued
- CAS No.
- 1009816-48-1
- Chemical Name:
- Thiamet G Discontinued
- Synonyms
- CS-1700;Thiamet G;Thiamet H;Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G_x000b_Discontinued;1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline;2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio;2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol;(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
- CBNumber:
- CB52485666
- Molecular Formula:
- C9H16N2O4S
- Molecular Weight:
- 248.3
- MDL Number:
- MFCD15144964
- MOL File:
- 1009816-48-1.mol
- MSDS File:
- SDS
| Boiling point | 483.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.74±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: ≥5mg/mL at warmed to 60°C |
| form | powder |
| pka | 13.17±0.70(Predicted) |
| color | white to beige |
| optical activity | [α]/D -21 to -26°, c = 0.3 in methanol |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | PPAIMZHKIXDJRN-UKPHHSARSA-N |
Thiamet G Discontinued price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0244 | Thiamet G ≥98% (HPLC) | 1009816-48-1 | 5mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0244 | Thiamet G ≥98% (HPLC) | 1009816-48-1 | 25mg | $505 | 2024-03-01 | Buy |
| Cayman Chemical | 13237 | Thiamet G ≥97% | 1009816-48-1 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 13237 | Thiamet G ≥97% | 1009816-48-1 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 13237 | Thiamet G ≥97% | 1009816-48-1 | 10mg | $133 | 2024-03-01 | Buy |
Thiamet G Discontinued Chemical Properties,Uses,Production
Description
Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki?= 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and?in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1?Stabilizes tau against aggregation and slows neurodegeneration.2?Thiamet G prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3?Elevates soluble tau species and reduces tauopathy in mouse models.4?Active?in vivo?and blood brain barrier permeable.
Uses
A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD. Anti-Alzheimer''s agent.
Uses
As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological
Biochem/physiol Actions
Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.
storage
Store at -20°C
References
1) Yuzwa?et al. (2008),?A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo; Nat. Chem. Biol.,?4?483 2) Yuzwa?et al. (2012),?Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation; Nat. Chem. Biol.?8?393 3) Yuzwa?et al. (2014),?Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice; Mol. Neurodegener.,?9?42 4) Hastings?et al.?(2017)?Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice;?Mol. Neurodegener.,?12?39
Thiamet G Discontinued Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from Thiamet G Discontinued manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-03-05 | Thiamet G Discontinued
1009816-48-1
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co | |
 |
2020-02-07 | Thiamet G
1009816-48-1
|
US $9.80 / KG | 1KG | ＞98%HPLC | 20 tons | Career Henan Chemical Co |
-
- Thiamet G Discontinued
1009816-48-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
-
- Thiamet G
1009816-48-1
- US $9.80 / KG
- ＞98%HPLC
- Career Henan Chemical Co