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ATN-224

ATN-224 Structure
ATN-224 structure
CAS No.
649749-10-0
Chemical Name:
ATN-224
Synonyms
ATN-224;WTX-101);ATN 224,ATN224;Choline tetrathiomolybdate;Bis(choline)tetrathioMolybdate;ATN-224 (Choline tetrathiomolybdate;CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101;2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate;bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide
CBNumber:
CB52582927
Molecular Formula:
C5H14MoNOS4-
Molecular Weight:
328.36
MDL Number:
MFCD25976790
MOL File:
649749-10-0.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:53
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ATN-224 Properties

storage temp. Store at -20°C
solubility DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM)
form A crystalline solid
NCI Dictionary of Cancer Terms ATN-224
FDA UNII FD57A79R4P

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

ATN-224 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3409 ATN-224 ≥95% (elemental analysis) 649749-10-0 5MG $81 2024-03-01 Buy
Sigma-Aldrich SML3409 ATN-224 ≥95% (elemental analysis) 649749-10-0 25MG $327 2024-03-01 Buy
Cayman Chemical 23553 ATN-224 ≥95% 649749-10-0 1mg $68 2024-03-01 Buy
Cayman Chemical 23553 ATN-224 ≥95% 649749-10-0 5mg $214 2024-03-01 Buy
Cayman Chemical 23553 ATN-224 ≥95% 649749-10-0 10mg $365 2024-03-01 Buy
Product number Packaging Price Buy
SML3409 5MG $81 Buy
SML3409 25MG $327 Buy
23553 1mg $68 Buy
23553 5mg $214 Buy
23553 10mg $365 Buy

ATN-224 Chemical Properties,Uses,Production

Description

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).

ATN-224 Preparation Products And Raw materials

Raw materials

Preparation Products

ATN-224 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33350 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2210 55
BeiJing Hwrk Chemicals Limted 0757-86329057 18501085097 sales3.gd@hwrkchemical.com China 7639 55
Lanzhou Angeli Biochemical Technology Co., Ltd. 0931-8235634 13321316780 1455540579@qq.com China 959 55
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
InvivoChem 		58
LEAPCHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
BeiJing Hwrk Chemicals Limted 55
Lanzhou Angeli Biochemical Technology Co., Ltd. 55
ATN-224 Bis(choline)tetrathioMolybdate ATN-224 (Choline tetrathiomolybdate WTX-101) Choline tetrathiomolybdate CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101 bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide 2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate ATN 224,ATN224 649749-10-0 2C5H14NOMoS4 C10H32MoN2O2S4