ATB 346
- CAS No.
- 1226895-20-0
- Chemical Name:
- ATB 346
- Synonyms
- ATB 346;ABT-346;CS-1282;Otenaproxesul;ATB-346, >=98%;ATB346;ATB 346;ATB 346,1226895-20-0;4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE;2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester
- CBNumber:
- CB52627347
- Molecular Formula:
- C21H19NO3S
- Molecular Weight:
- 365.45
- MDL Number:
- MFCD19443776
- MOL File:
- 1226895-20-0.mol
- MSDS File:
- SDS
| Boiling point | 561.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.261±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO |
| form | solid |
| pka | 12.37±0.29(Predicted) |
| FDA UNII | 3096O7WP53 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H317 | |||||||||
| Precautionary statements | P261-P264-P270-P272-P280-P301+P312-P330-P302+P352-P305+P351+P338-P333+P313-P321-P337+P313-P363-P501 | |||||||||
| NFPA 704 |
|
ATB 346 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16234 | ATB-346 ≥98% | 1226895-20-0 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 16234 | ATB-346 ≥98% | 1226895-20-0 | 50mg | $468 | 2024-03-01 | Buy |
| Cayman Chemical | 16234 | ATB-346 ≥98% | 1226895-20-0 | 1mg | $55 | 2021-12-16 | Buy |
| Cayman Chemical | 16234 | ATB-346 ≥98% | 1226895-20-0 | 10mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 16234 | ATB-346 ≥98% | 1226895-20-0 | 25mg | $288 | 2024-03-01 | Buy |
ATB 346 Chemical Properties,Uses,Production
Description
ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen . It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 μM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 μmol/kg. ATB-346 (30 μmol/kg) improves motor function in a mouse model of spinal cord injury.
References
[1] wallace j l, caliendo g, santagada v, et al. markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (atb-346). british journal of pharmacology, 2010, 159(6): 1236-1246.
ATB 346 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
